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High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer.
J Soc Gynecol Investig. 2004 May; 11(4):203-6.JS

Abstract

OBJECTIVE

The aim of the present study was to evaluate the concentrations of activin A in the peritoneal fluid of women with epithelial (serous) ovarian cancer.

METHODS

A group of 160 women was studied and divided in four subgroups as follows: 1) serous ovarian carcinoma (n = 32); 2) serous ovarian cystadenoma (n = 20); 3) endometriosis (n = 53); and 4) healthy controls (n = 55), including both fertile (n = 32) and postmenopausal women (n = 23). Specimens of peritoneal fluid were collected during surgical interventions, and activin A was quantified using a specific two-site enzyme immunoassay.

RESULTS

Peritoneal fluid activin A concentrations in women with ovarian carcinoma were about five-fold higher than those found in the control group (median [interquartile range] = 7.60 [2.85-10.15] and 1.50 [1.00-2.50] ng/mL, respectively, P <.001). In contrast, the women with benign serous cystadenoma had peritoneal fluid activin A concentrations (1.50 [1.0-2.70] ng/mL) similar to those of the control group. High peritoneal fluid activin A levels (>2 multiples of the mean) distinguished carcinoma from cystadenoma with a sensitivity of 72% and a specificity of 80%. The follow-up of nine patients with stage IIIc ovarian cancer showed no apparent relationship between the peritoneal fluid activin A levels and overall survival. No significant difference in peritoneal fluid activin A concentrations between patients with endometriosis and control women was observed.

CONCLUSION

Most women with serous ovarian carcinoma had high concentrations of activin A in the peritoneal fluid, supporting a possible role of this growth factor in ovarian cancer.

Authors+Show Affiliations

Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15120692

Citation

Cobellis, Luigi, et al. "High Concentrations of Activin a in the Peritoneal Fluid of Women With Epithelial Ovarian Cancer." Journal of the Society for Gynecologic Investigation, vol. 11, no. 4, 2004, pp. 203-6.
Cobellis L, Reis FM, Luisi S, et al. High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer. J Soc Gynecol Investig. 2004;11(4):203-6.
Cobellis, L., Reis, F. M., Luisi, S., Danero, S., Pirtoli, L., Scambia, G., & Petraglia, F. (2004). High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer. Journal of the Society for Gynecologic Investigation, 11(4), 203-6.
Cobellis L, et al. High Concentrations of Activin a in the Peritoneal Fluid of Women With Epithelial Ovarian Cancer. J Soc Gynecol Investig. 2004;11(4):203-6. PubMed PMID: 15120692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer. AU - Cobellis,Luigi, AU - Reis,Fernando M, AU - Luisi,Stefano, AU - Danero,Secondo, AU - Pirtoli,Luigi, AU - Scambia,Giovanni, AU - Petraglia,Felice, PY - 2004/5/4/pubmed PY - 2004/12/16/medline PY - 2004/5/4/entrez SP - 203 EP - 6 JF - Journal of the Society for Gynecologic Investigation JO - J. Soc. Gynecol. Investig. VL - 11 IS - 4 N2 - OBJECTIVE: The aim of the present study was to evaluate the concentrations of activin A in the peritoneal fluid of women with epithelial (serous) ovarian cancer. METHODS: A group of 160 women was studied and divided in four subgroups as follows: 1) serous ovarian carcinoma (n = 32); 2) serous ovarian cystadenoma (n = 20); 3) endometriosis (n = 53); and 4) healthy controls (n = 55), including both fertile (n = 32) and postmenopausal women (n = 23). Specimens of peritoneal fluid were collected during surgical interventions, and activin A was quantified using a specific two-site enzyme immunoassay. RESULTS: Peritoneal fluid activin A concentrations in women with ovarian carcinoma were about five-fold higher than those found in the control group (median [interquartile range] = 7.60 [2.85-10.15] and 1.50 [1.00-2.50] ng/mL, respectively, P <.001). In contrast, the women with benign serous cystadenoma had peritoneal fluid activin A concentrations (1.50 [1.0-2.70] ng/mL) similar to those of the control group. High peritoneal fluid activin A levels (>2 multiples of the mean) distinguished carcinoma from cystadenoma with a sensitivity of 72% and a specificity of 80%. The follow-up of nine patients with stage IIIc ovarian cancer showed no apparent relationship between the peritoneal fluid activin A levels and overall survival. No significant difference in peritoneal fluid activin A concentrations between patients with endometriosis and control women was observed. CONCLUSION: Most women with serous ovarian carcinoma had high concentrations of activin A in the peritoneal fluid, supporting a possible role of this growth factor in ovarian cancer. SN - 1071-5576 UR - https://www.unboundmedicine.com/medline/citation/15120692/High_concentrations_of_activin_A_in_the_peritoneal_fluid_of_women_with_epithelial_ovarian_cancer_ L2 - http://www.diseaseinfosearch.org/result/5509 DB - PRIME DP - Unbound Medicine ER -