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Nuclear export of mRNA: from the site of transcription to the cytoplasm.
Exp Cell Res. 2004 May 15; 296(1):12-20.EC

Abstract

Cellular mRNAs are produced in the nucleus and must be exported to the cytoplasm to allow for their translation into proteins. Recruitment of export factors to nascent mRNA starts cotranscriptionally and involves elaborate systems of quality control. Correctly processed mRNAs are committed for export in the form of large ribonucleoprotein complexes (mRNPs). Translocation of mRNPs through the nuclear pore complex (NPC) is mediated by a conserved heterodimeric transport receptor (NXF1/p15 in metazoa and Mex67p/Mtr2p in yeast) that bridges the interaction between the mRNP and the NPC. In this review, we describe the cis- and trans-requirements for mRNA export as well as the different mechanisms of recruiting export factors to mRNPs. We also discuss the significance of linking mRNA export with both downstream and upstream events in gene expression.

Authors+Show Affiliations

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15120988

Citation

Erkmann, Judith A., and Ulrike Kutay. "Nuclear Export of mRNA: From the Site of Transcription to the Cytoplasm." Experimental Cell Research, vol. 296, no. 1, 2004, pp. 12-20.
Erkmann JA, Kutay U. Nuclear export of mRNA: from the site of transcription to the cytoplasm. Exp Cell Res. 2004;296(1):12-20.
Erkmann, J. A., & Kutay, U. (2004). Nuclear export of mRNA: from the site of transcription to the cytoplasm. Experimental Cell Research, 296(1), 12-20.
Erkmann JA, Kutay U. Nuclear Export of mRNA: From the Site of Transcription to the Cytoplasm. Exp Cell Res. 2004 May 15;296(1):12-20. PubMed PMID: 15120988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nuclear export of mRNA: from the site of transcription to the cytoplasm. AU - Erkmann,Judith A, AU - Kutay,Ulrike, PY - 2003/12/22/received PY - 2004/5/4/pubmed PY - 2004/6/21/medline PY - 2004/5/4/entrez SP - 12 EP - 20 JF - Experimental cell research JO - Exp Cell Res VL - 296 IS - 1 N2 - Cellular mRNAs are produced in the nucleus and must be exported to the cytoplasm to allow for their translation into proteins. Recruitment of export factors to nascent mRNA starts cotranscriptionally and involves elaborate systems of quality control. Correctly processed mRNAs are committed for export in the form of large ribonucleoprotein complexes (mRNPs). Translocation of mRNPs through the nuclear pore complex (NPC) is mediated by a conserved heterodimeric transport receptor (NXF1/p15 in metazoa and Mex67p/Mtr2p in yeast) that bridges the interaction between the mRNP and the NPC. In this review, we describe the cis- and trans-requirements for mRNA export as well as the different mechanisms of recruiting export factors to mRNPs. We also discuss the significance of linking mRNA export with both downstream and upstream events in gene expression. SN - 0014-4827 UR - https://www.unboundmedicine.com/medline/citation/15120988/Nuclear_export_of_mRNA:_from_the_site_of_transcription_to_the_cytoplasm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014482704001235 DB - PRIME DP - Unbound Medicine ER -