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Treatment of venous leg ulcers with Dermagraft.
Eur J Vasc Endovasc Surg. 2004 Jun; 27(6):666-72.EJ

Abstract

BACKGROUND

A number of different treatment approaches have been recommended for the treatment of venous ulceration, including local ulcer treatment, compression and drug therapy. Recent advances in tissue engineering have resulted in living tissues being developed for cutaneous wound repair and skin replacement. The aim of this pilot study was to compare the rate of healing of venous ulcers in patients treated with Dermagraft (a human fibroblast-derived dermal replacement) and compression therapy or compression therapy alone.

METHODS

A total of 18 patients with venous ulceration of the leg were recruited into the pilot study. Ten patients were treated with Dermagraft and compression therapy, and eight patients were treated with compression therapy alone. Healing was assessed by ulcer tracing and computerised planimetry. Skin perfusion was measured by laser Doppler.

RESULTS

Five (50%) of the patients treated with Dermagraft and one (12.5%) control patient had healed by the end of the 12-week study period (NS). The total ulcer area rate of healing and linear rate of healing was significantly improved in patients treated with Dermagraft (P=0.001 and P=0.006, respectively, Mann-Whitney U-test). The number of capillaries increased in both the treatment and control group. Peri-ulcer skin perfusion increased by 20% in patients treated with Dermagraft, compared with 4.9% in the control group.

CONCLUSION

The data from this small pilot study suggests that Dermagraft is associated with improved healing of venous ulceration. Following this pilot study, further clinical studies are needed to confirm the validity of these results in 'hard to heal' venous leg ulcers.

Authors+Show Affiliations

Department of General Surgery, Faculty of Medicine, Shebinel-Kom, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15121121

Citation

Omar, A A., et al. "Treatment of Venous Leg Ulcers With Dermagraft." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 27, no. 6, 2004, pp. 666-72.
Omar AA, Mavor AI, Jones AM, et al. Treatment of venous leg ulcers with Dermagraft. Eur J Vasc Endovasc Surg. 2004;27(6):666-72.
Omar, A. A., Mavor, A. I., Jones, A. M., & Homer-Vanniasinkam, S. (2004). Treatment of venous leg ulcers with Dermagraft. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 27(6), 666-72.
Omar AA, et al. Treatment of Venous Leg Ulcers With Dermagraft. Eur J Vasc Endovasc Surg. 2004;27(6):666-72. PubMed PMID: 15121121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of venous leg ulcers with Dermagraft. AU - Omar,A A, AU - Mavor,A I D, AU - Jones,A M, AU - Homer-Vanniasinkam,S, PY - 2004/03/01/accepted PY - 2004/5/4/pubmed PY - 2004/6/21/medline PY - 2004/5/4/entrez SP - 666 EP - 72 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 27 IS - 6 N2 - BACKGROUND: A number of different treatment approaches have been recommended for the treatment of venous ulceration, including local ulcer treatment, compression and drug therapy. Recent advances in tissue engineering have resulted in living tissues being developed for cutaneous wound repair and skin replacement. The aim of this pilot study was to compare the rate of healing of venous ulcers in patients treated with Dermagraft (a human fibroblast-derived dermal replacement) and compression therapy or compression therapy alone. METHODS: A total of 18 patients with venous ulceration of the leg were recruited into the pilot study. Ten patients were treated with Dermagraft and compression therapy, and eight patients were treated with compression therapy alone. Healing was assessed by ulcer tracing and computerised planimetry. Skin perfusion was measured by laser Doppler. RESULTS: Five (50%) of the patients treated with Dermagraft and one (12.5%) control patient had healed by the end of the 12-week study period (NS). The total ulcer area rate of healing and linear rate of healing was significantly improved in patients treated with Dermagraft (P=0.001 and P=0.006, respectively, Mann-Whitney U-test). The number of capillaries increased in both the treatment and control group. Peri-ulcer skin perfusion increased by 20% in patients treated with Dermagraft, compared with 4.9% in the control group. CONCLUSION: The data from this small pilot study suggests that Dermagraft is associated with improved healing of venous ulceration. Following this pilot study, further clinical studies are needed to confirm the validity of these results in 'hard to heal' venous leg ulcers. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/15121121/Treatment_of_venous_leg_ulcers_with_Dermagraft_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078588404001236 DB - PRIME DP - Unbound Medicine ER -