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Limited long-term naive CD4+ T cell reconstitution in patients experiencing viral load rebounds during HAART.
J Med Virol. 2004 Jun; 73(2):235-43.JM

Abstract

Long-term (3.5 years) immune reconstitution in relation to viral load response was determined. Plasma HIV-1 RNA was suppressed in 40 patients (full responders) up to 42 months, and 17 patients achieved partial response. The measurements of CD4(+) and CD8(+) T lymphocyte subsets (CD45RA, CD45RACD62L, CD45RO, CD28, CD38) were carried out by flow cytometry. Full responders had a significant increase of CD4(+) and all CD4(+) T subsets both up to 6 and from 6 to 42 months, while the increase for partial responders was only up to 6 months. By 6 months, higher slopes were observed in full versus partial responders in the % of CD28 on CD4(+) and the % of CD4(+) memory subset and in both naïve and memory CD4(+) subsets from 6 to 42 months. The percentage of CD8(+) and its subsets was decreased significantly in full responders both up to 6 and from 6 to 42 months (except for an increase in the CD8(+)CD45RA(+) CD62L(+) cells), while in partial responders this decrease was only up to 6 months. Lower slopes were observed in full versus partial responders from 6 to 42 months in the percentages of CD8(+), CD8(+)CD45RO(+), CD8(+)CD28(-), and CD8(+)CD38(+) T cells. In conclusion, full responders have a stronger long-term naive CD4(+) T cell subset reconstitution than partial responders.

Authors+Show Affiliations

Department of Immunology, Laiko General Hospital, Athens, Greece. choremi-pap@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15122798

Citation

Choremi-Papadopoulou, H, et al. "Limited Long-term Naive CD4+ T Cell Reconstitution in Patients Experiencing Viral Load Rebounds During HAART." Journal of Medical Virology, vol. 73, no. 2, 2004, pp. 235-43.
Choremi-Papadopoulou H, Tsalimalma K, Dafni U, et al. Limited long-term naive CD4+ T cell reconstitution in patients experiencing viral load rebounds during HAART. J Med Virol. 2004;73(2):235-43.
Choremi-Papadopoulou, H., Tsalimalma, K., Dafni, U., Dimitracopoulou, A., & Kordossis, T. (2004). Limited long-term naive CD4+ T cell reconstitution in patients experiencing viral load rebounds during HAART. Journal of Medical Virology, 73(2), 235-43.
Choremi-Papadopoulou H, et al. Limited Long-term Naive CD4+ T Cell Reconstitution in Patients Experiencing Viral Load Rebounds During HAART. J Med Virol. 2004;73(2):235-43. PubMed PMID: 15122798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limited long-term naive CD4+ T cell reconstitution in patients experiencing viral load rebounds during HAART. AU - Choremi-Papadopoulou,H, AU - Tsalimalma,K, AU - Dafni,U, AU - Dimitracopoulou,A, AU - Kordossis,T, PY - 2004/5/4/pubmed PY - 2004/9/4/medline PY - 2004/5/4/entrez SP - 235 EP - 43 JF - Journal of medical virology JO - J Med Virol VL - 73 IS - 2 N2 - Long-term (3.5 years) immune reconstitution in relation to viral load response was determined. Plasma HIV-1 RNA was suppressed in 40 patients (full responders) up to 42 months, and 17 patients achieved partial response. The measurements of CD4(+) and CD8(+) T lymphocyte subsets (CD45RA, CD45RACD62L, CD45RO, CD28, CD38) were carried out by flow cytometry. Full responders had a significant increase of CD4(+) and all CD4(+) T subsets both up to 6 and from 6 to 42 months, while the increase for partial responders was only up to 6 months. By 6 months, higher slopes were observed in full versus partial responders in the % of CD28 on CD4(+) and the % of CD4(+) memory subset and in both naïve and memory CD4(+) subsets from 6 to 42 months. The percentage of CD8(+) and its subsets was decreased significantly in full responders both up to 6 and from 6 to 42 months (except for an increase in the CD8(+)CD45RA(+) CD62L(+) cells), while in partial responders this decrease was only up to 6 months. Lower slopes were observed in full versus partial responders from 6 to 42 months in the percentages of CD8(+), CD8(+)CD45RO(+), CD8(+)CD28(-), and CD8(+)CD38(+) T cells. In conclusion, full responders have a stronger long-term naive CD4(+) T cell subset reconstitution than partial responders. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/15122798/Limited_long_term_naive_CD4+_T_cell_reconstitution_in_patients_experiencing_viral_load_rebounds_during_HAART_ DB - PRIME DP - Unbound Medicine ER -