Tags

Type your tag names separated by a space and hit enter

Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18.
J Med Virol. 2004 Jun; 73(2):289-94.JM

Abstract

In order to understand early events in the immune response to respiratory syncytial virus (RSV) infection, we studied the presence of various chemokines and cytokines in respiratory secretions of human infants with RSV infection. Interferon gamma (IFNgamma) was present in 30/39 (76.9%) subjects tested, but the IFNgamma-inducing cytokines interleukin (IL)12 and IL18 were detectable in 6/40 (15%) and 11/38 (28.9%) subjects, respectively. Quantities of IL12 and IL18 did not correlate with those of IFNgamma. IL18, but neither IFNgamma nor IL12 was found in significantly greater concentrations in subjects with mild, nonhypoxic forms of bronchiolitis than in those with upper respiratory illness alone or hypoxic bronchiolitis. The findings suggest that IFNgamma may be induced independently of the activities of IL12 and IL18 during RSV infection. Immune responses characterized by relatively greater release of IL18 may be associated with milder forms of bronchiolitis.

Authors+Show Affiliations

Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15122806

Citation

Garofalo, Roberto P., et al. "Production of Interferon Gamma in Respiratory Syncytial Virus Infection of Humans Is Not Associated With Interleukins 12 and 18." Journal of Medical Virology, vol. 73, no. 2, 2004, pp. 289-94.
Garofalo RP, Hintz KH, Hill V, et al. Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. J Med Virol. 2004;73(2):289-94.
Garofalo, R. P., Hintz, K. H., Hill, V., Ogra, P. L., & Welliver, R. C. (2004). Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. Journal of Medical Virology, 73(2), 289-94.
Garofalo RP, et al. Production of Interferon Gamma in Respiratory Syncytial Virus Infection of Humans Is Not Associated With Interleukins 12 and 18. J Med Virol. 2004;73(2):289-94. PubMed PMID: 15122806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. AU - Garofalo,Roberto P, AU - Hintz,Karen H, AU - Hill,Vanessa, AU - Ogra,Pearay L, AU - Welliver,Robert C,Sr PY - 2004/5/4/pubmed PY - 2004/9/4/medline PY - 2004/5/4/entrez SP - 289 EP - 94 JF - Journal of medical virology JO - J Med Virol VL - 73 IS - 2 N2 - In order to understand early events in the immune response to respiratory syncytial virus (RSV) infection, we studied the presence of various chemokines and cytokines in respiratory secretions of human infants with RSV infection. Interferon gamma (IFNgamma) was present in 30/39 (76.9%) subjects tested, but the IFNgamma-inducing cytokines interleukin (IL)12 and IL18 were detectable in 6/40 (15%) and 11/38 (28.9%) subjects, respectively. Quantities of IL12 and IL18 did not correlate with those of IFNgamma. IL18, but neither IFNgamma nor IL12 was found in significantly greater concentrations in subjects with mild, nonhypoxic forms of bronchiolitis than in those with upper respiratory illness alone or hypoxic bronchiolitis. The findings suggest that IFNgamma may be induced independently of the activities of IL12 and IL18 during RSV infection. Immune responses characterized by relatively greater release of IL18 may be associated with milder forms of bronchiolitis. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/15122806/Production_of_interferon_gamma_in_respiratory_syncytial_virus_infection_of_humans_is_not_associated_with_interleukins_12_and_18_ L2 - https://doi.org/10.1002/jmv.20089 DB - PRIME DP - Unbound Medicine ER -