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The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat.

Abstract

The aim of this study was to investigate the GH-IGF-I axis in healthy adults and its relationship to obesity. We studied 268 subjects: 134 men and 134 women, and determined anthropometric and body composition variables. Serum total IGF-I was measured by radioimmunoassay, serum free IGF-I concentrations by enzyme linked immunosorbant assay and serum IGFBP3 concentrations by radioimmunoassay. In men, we observed a decrease in total IGF-I, free IGF-I and IGFBP-3 throughout decades. In women, the body mass index and fat mass were higher throughout decades, and we observed a similar decrease to that in men in total IGF-I, free IGF-I and IGFBP3. In men with obesity, as measured by body fat, free IGF-I concentrations were lower than those without obesity; in women with obesity, total IGF-I concentrations and free IGF-I concentrations were lower than in those with obesity. These changes were observed in relationship to obesity when the subjects were adjusted for differences in age. We showed that in controls randomly selected, the GH-IGF-I axis component concentrations that decrease with increasing age are lower in obesity, especially in women, and that this decrease is related to body mass index and body fat.

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  • Authors+Show Affiliations

    ,

    Endocrinology Service, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

    , , , ,

    Source

    MeSH

    Adipose Tissue
    Adult
    Age Factors
    Aged
    Aging
    Body Composition
    Body Mass Index
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Insulin-Like Growth Factor Binding Protein 3
    Insulin-Like Growth Factor I
    Male
    Middle Aged
    Obesity
    Radioimmunoassay
    Sex Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15123168

    Citation

    Gómez, José Manuel, et al. "The IGF-I System Component Concentrations That Decrease With Ageing Are Lower in Obesity in Relationship to Body Mass Index and Body Fat." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 14, no. 2, 2004, pp. 91-6.
    Gómez JM, Maravall FJ, Gómez N, et al. The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. Growth Horm IGF Res. 2004;14(2):91-6.
    Gómez, J. M., Maravall, F. J., Gómez, N., Navarro, M. A., Casamitjana, R., & Soler, J. (2004). The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 14(2), pp. 91-6.
    Gómez JM, et al. The IGF-I System Component Concentrations That Decrease With Ageing Are Lower in Obesity in Relationship to Body Mass Index and Body Fat. Growth Horm IGF Res. 2004;14(2):91-6. PubMed PMID: 15123168.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. AU - Gómez,José Manuel, AU - Maravall,Francisco Javier, AU - Gómez,Núria, AU - Navarro,Miguel Angel, AU - Casamitjana,Roser, AU - Soler,Juan, PY - 2003/09/10/received PY - 2003/11/26/revised PY - 2003/11/26/accepted PY - 2004/5/5/pubmed PY - 2004/10/9/medline PY - 2004/5/5/entrez SP - 91 EP - 6 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm. IGF Res. VL - 14 IS - 2 N2 - The aim of this study was to investigate the GH-IGF-I axis in healthy adults and its relationship to obesity. We studied 268 subjects: 134 men and 134 women, and determined anthropometric and body composition variables. Serum total IGF-I was measured by radioimmunoassay, serum free IGF-I concentrations by enzyme linked immunosorbant assay and serum IGFBP3 concentrations by radioimmunoassay. In men, we observed a decrease in total IGF-I, free IGF-I and IGFBP-3 throughout decades. In women, the body mass index and fat mass were higher throughout decades, and we observed a similar decrease to that in men in total IGF-I, free IGF-I and IGFBP3. In men with obesity, as measured by body fat, free IGF-I concentrations were lower than those without obesity; in women with obesity, total IGF-I concentrations and free IGF-I concentrations were lower than in those with obesity. These changes were observed in relationship to obesity when the subjects were adjusted for differences in age. We showed that in controls randomly selected, the GH-IGF-I axis component concentrations that decrease with increasing age are lower in obesity, especially in women, and that this decrease is related to body mass index and body fat. SN - 1096-6374 UR - https://www.unboundmedicine.com/medline/citation/15123168/The_IGF_I_system_component_concentrations_that_decrease_with_ageing_are_lower_in_obesity_in_relationship_to_body_mass_index_and_body_fat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096637403001588 DB - PRIME DP - Unbound Medicine ER -