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The auxotrophic aroA mutant of Aeromonas hydrophila as a live attenuated vaccine against A. salmonicida infections in rainbow trout (Oncorhynchus mykiss).
Fish Shellfish Immunol. 2004 Feb; 16(2):193-206.FS

Abstract

An auxotrophic aroA mutant of the Aeromonas hydrophila AG2 strain is a live attenuated vaccine against A. hydrophila infection in rainbow trout (Oncorhynchus mykiss). The protection conferred by the live attenuated vaccine against A. salmonicida strains is reported here, and several parameters of the specific and non-specific immune response in vaccinated trout were characterised. Vaccination with a dose of 10(7)cells/fish of the aroA mutant elicited significant protection against the Hooke and DK30 strains of A. salmonicida (relative percent survival RPS >60%). This cross-protection correlated moderately with the activation of the humoral and cellular specific immune responses, which show cross-reactivity against antigens shared by the two bacterial species, and a moderate increase in the lysozyme and antiprotease activities in the serum of vaccinated trout.

Authors+Show Affiliations

Departmento de Biología Celular, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, 24071 León, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15123323

Citation

Vivas, Jose, et al. "The Auxotrophic aroA Mutant of Aeromonas Hydrophila as a Live Attenuated Vaccine Against A. Salmonicida Infections in Rainbow Trout (Oncorhynchus Mykiss)." Fish & Shellfish Immunology, vol. 16, no. 2, 2004, pp. 193-206.
Vivas J, Riaño J, Carracedo B, et al. The auxotrophic aroA mutant of Aeromonas hydrophila as a live attenuated vaccine against A. salmonicida infections in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2004;16(2):193-206.
Vivas, J., Riaño, J., Carracedo, B., Razquin, B. E., López-Fierro, P., Naharro, G., & Villena, A. J. (2004). The auxotrophic aroA mutant of Aeromonas hydrophila as a live attenuated vaccine against A. salmonicida infections in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology, 16(2), 193-206.
Vivas J, et al. The Auxotrophic aroA Mutant of Aeromonas Hydrophila as a Live Attenuated Vaccine Against A. Salmonicida Infections in Rainbow Trout (Oncorhynchus Mykiss). Fish Shellfish Immunol. 2004;16(2):193-206. PubMed PMID: 15123323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The auxotrophic aroA mutant of Aeromonas hydrophila as a live attenuated vaccine against A. salmonicida infections in rainbow trout (Oncorhynchus mykiss). AU - Vivas,Jose, AU - Riaño,Jorge, AU - Carracedo,Begoña, AU - Razquin,Blanca E, AU - López-Fierro,Pilar, AU - Naharro,Germán, AU - Villena,Alberto J, PY - 2003/01/30/received PY - 2003/05/27/accepted PY - 2004/5/5/pubmed PY - 2004/6/21/medline PY - 2004/5/5/entrez SP - 193 EP - 206 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 16 IS - 2 N2 - An auxotrophic aroA mutant of the Aeromonas hydrophila AG2 strain is a live attenuated vaccine against A. hydrophila infection in rainbow trout (Oncorhynchus mykiss). The protection conferred by the live attenuated vaccine against A. salmonicida strains is reported here, and several parameters of the specific and non-specific immune response in vaccinated trout were characterised. Vaccination with a dose of 10(7)cells/fish of the aroA mutant elicited significant protection against the Hooke and DK30 strains of A. salmonicida (relative percent survival RPS >60%). This cross-protection correlated moderately with the activation of the humoral and cellular specific immune responses, which show cross-reactivity against antigens shared by the two bacterial species, and a moderate increase in the lysozyme and antiprotease activities in the serum of vaccinated trout. SN - 1050-4648 UR - https://www.unboundmedicine.com/medline/citation/15123323/The_auxotrophic_aroA_mutant_of_Aeromonas_hydrophila_as_a_live_attenuated_vaccine_against_A__salmonicida_infections_in_rainbow_trout__Oncorhynchus_mykiss__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050464803000780 DB - PRIME DP - Unbound Medicine ER -