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Hippocampus and entorhinal cortex in mild cognitive impairment and early AD.
Neurobiol Aging. 2004 Mar; 25(3):303-10.NA

Abstract

Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus and entorhinal cortex (ERC) in 59 controls, 65 individuals with mild cognitive impairment (MCI) and 48 patients with AD. The controls and individuals with MCI were derived from population-based cohorts. Volumes of the hippocampus and ERC were significantly reduced in the following order: control > MCI > AD. Stepwise discriminant function analysis showed that the most efficient overall classification between controls and individuals with MCI subjects was achieved with ERC measurements (65.9%). However, the best overall classification between controls and AD patients (90.7%), and between individuals with MCI and AD patients (82.3%) was achieved with hippocampal volumes. Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, P.O. Box 1627, FIN-70 211 Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15123335

Citation

Pennanen, Corina, et al. "Hippocampus and Entorhinal Cortex in Mild Cognitive Impairment and Early AD." Neurobiology of Aging, vol. 25, no. 3, 2004, pp. 303-10.
Pennanen C, Kivipelto M, Tuomainen S, et al. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging. 2004;25(3):303-10.
Pennanen, C., Kivipelto, M., Tuomainen, S., Hartikainen, P., Hänninen, T., Laakso, M. P., Hallikainen, M., Vanhanen, M., Nissinen, A., Helkala, E. L., Vainio, P., Vanninen, R., Partanen, K., & Soininen, H. (2004). Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiology of Aging, 25(3), 303-10.
Pennanen C, et al. Hippocampus and Entorhinal Cortex in Mild Cognitive Impairment and Early AD. Neurobiol Aging. 2004;25(3):303-10. PubMed PMID: 15123335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. AU - Pennanen,Corina, AU - Kivipelto,Miia, AU - Tuomainen,Susanna, AU - Hartikainen,Päivi, AU - Hänninen,Tuomo, AU - Laakso,Mikko P, AU - Hallikainen,Merja, AU - Vanhanen,Matti, AU - Nissinen,Aulikki, AU - Helkala,Eeva-Liisa, AU - Vainio,Pauli, AU - Vanninen,Ritva, AU - Partanen,Kaarina, AU - Soininen,Hilkka, PY - 2002/10/28/received PY - 2003/03/14/revised PY - 2003/03/27/accepted PY - 2004/5/5/pubmed PY - 2004/7/16/medline PY - 2004/5/5/entrez SP - 303 EP - 10 JF - Neurobiology of aging JO - Neurobiol Aging VL - 25 IS - 3 N2 - Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus and entorhinal cortex (ERC) in 59 controls, 65 individuals with mild cognitive impairment (MCI) and 48 patients with AD. The controls and individuals with MCI were derived from population-based cohorts. Volumes of the hippocampus and ERC were significantly reduced in the following order: control > MCI > AD. Stepwise discriminant function analysis showed that the most efficient overall classification between controls and individuals with MCI subjects was achieved with ERC measurements (65.9%). However, the best overall classification between controls and AD patients (90.7%), and between individuals with MCI and AD patients (82.3%) was achieved with hippocampal volumes. Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15123335/Hippocampus_and_entorhinal_cortex_in_mild_cognitive_impairment_and_early_AD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458003000848 DB - PRIME DP - Unbound Medicine ER -