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Moderating effects of major depression on patterns of comorbidity in patients with panic disorder.
Psychiatry Res. 2004 Apr 30; 126(2):143-9.PR

Abstract

Given the high rate of co-occurring major depression in patients with panic disorder, it is unclear whether patterns of comorbidity in individuals with panic disorder reported in the literature are associated with panic disorder or with the presence of major depression. Subjects were 231 adult subjects with panic disorder and major depression (n=102), panic disorder without comorbid major depression (n=29), major depression without comorbid panic disorder (n=39), and neither panic disorder nor major depression (n=61). Subjects were comprehensively assessed with structured diagnostic interviews that examined psychopathology across the life cycle. Panic disorder, independently of comorbidity with major depression, was significantly associated with comorbid separation anxiety disorder, simple phobia, obsessive-compulsive disorder, generalized anxiety disorder, and agoraphobia. Major depression, independently of comorbidity with panic disorder, was significantly associated with comorbidity with psychoactive substance use disorders and childhood disruptive behavior disorders. Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults.

Authors+Show Affiliations

Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA. jbiederman@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15123393

Citation

Biederman, Joseph, et al. "Moderating Effects of Major Depression On Patterns of Comorbidity in Patients With Panic Disorder." Psychiatry Research, vol. 126, no. 2, 2004, pp. 143-9.
Biederman J, Petty C, Faraone SV, et al. Moderating effects of major depression on patterns of comorbidity in patients with panic disorder. Psychiatry Res. 2004;126(2):143-9.
Biederman, J., Petty, C., Faraone, S. V., Hirshfeld-Becker, D., Pollack, M. H., Henin, A., Gilbert, J., & Rosenbaum, J. F. (2004). Moderating effects of major depression on patterns of comorbidity in patients with panic disorder. Psychiatry Research, 126(2), 143-9.
Biederman J, et al. Moderating Effects of Major Depression On Patterns of Comorbidity in Patients With Panic Disorder. Psychiatry Res. 2004 Apr 30;126(2):143-9. PubMed PMID: 15123393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderating effects of major depression on patterns of comorbidity in patients with panic disorder. AU - Biederman,Joseph, AU - Petty,Carter, AU - Faraone,Stephen V, AU - Hirshfeld-Becker,Dina, AU - Pollack,Mark H, AU - Henin,Aude, AU - Gilbert,Jennifer, AU - Rosenbaum,Jerrold F, PY - 2003/10/10/received PY - 2004/02/02/revised PY - 2004/02/02/accepted PY - 2004/5/5/pubmed PY - 2004/9/24/medline PY - 2004/5/5/entrez SP - 143 EP - 9 JF - Psychiatry research JO - Psychiatry Res VL - 126 IS - 2 N2 - Given the high rate of co-occurring major depression in patients with panic disorder, it is unclear whether patterns of comorbidity in individuals with panic disorder reported in the literature are associated with panic disorder or with the presence of major depression. Subjects were 231 adult subjects with panic disorder and major depression (n=102), panic disorder without comorbid major depression (n=29), major depression without comorbid panic disorder (n=39), and neither panic disorder nor major depression (n=61). Subjects were comprehensively assessed with structured diagnostic interviews that examined psychopathology across the life cycle. Panic disorder, independently of comorbidity with major depression, was significantly associated with comorbid separation anxiety disorder, simple phobia, obsessive-compulsive disorder, generalized anxiety disorder, and agoraphobia. Major depression, independently of comorbidity with panic disorder, was significantly associated with comorbidity with psychoactive substance use disorders and childhood disruptive behavior disorders. Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/15123393/Moderating_effects_of_major_depression_on_patterns_of_comorbidity_in_patients_with_panic_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165178104000332 DB - PRIME DP - Unbound Medicine ER -