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Cardioprotective effects of carvedilol on acute autoimmune myocarditis.
Mol Cell Biochem. 2004 Apr; 259(1-2):223-7.MC

Abstract

We investigated whether carvedilol protects against experimental autoimmune myocarditis (EAM) attributing to antioxidant properties. Acute EAM was induced by porcine cardiac myosin in Lewis rats. We orally administered a vehicle, various dosages of carvedilol, metoprolol, or propranolol to rats with EAM for 3 weeks. Three beta-blockers decreased heart rates to the same extent. Carvedilol, but not metoprolol or propranolol, markedly reduced the severity of myocarditis at the two different dosages. Only carvedilol decreased the myocardial protein carbonyl contents, and also decreased the myocardial thiobarbituric acid reactive substance products in rats with EAM. Accordingly, carvedilol protects against acute EAM in rats, and this superior cardioprotective effect of carvedilol to metoprolol and propranolol may be due to the antioxidant properties in addition to the hemodynamic modifications.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15124928

Citation

Yuan, Zuyi, et al. "Cardioprotective Effects of Carvedilol On Acute Autoimmune Myocarditis." Molecular and Cellular Biochemistry, vol. 259, no. 1-2, 2004, pp. 223-7.
Yuan Z, Shioji K, Nimata M, et al. Cardioprotective effects of carvedilol on acute autoimmune myocarditis. Mol Cell Biochem. 2004;259(1-2):223-7.
Yuan, Z., Shioji, K., Nimata, M., & Kishimoto, C. (2004). Cardioprotective effects of carvedilol on acute autoimmune myocarditis. Molecular and Cellular Biochemistry, 259(1-2), 223-7.
Yuan Z, et al. Cardioprotective Effects of Carvedilol On Acute Autoimmune Myocarditis. Mol Cell Biochem. 2004;259(1-2):223-7. PubMed PMID: 15124928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardioprotective effects of carvedilol on acute autoimmune myocarditis. AU - Yuan,Zuyi, AU - Shioji,Keisuke, AU - Nimata,Masaomi, AU - Kishimoto,Chiharu, PY - 2004/5/6/pubmed PY - 2005/1/26/medline PY - 2004/5/6/entrez SP - 223 EP - 7 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 259 IS - 1-2 N2 - We investigated whether carvedilol protects against experimental autoimmune myocarditis (EAM) attributing to antioxidant properties. Acute EAM was induced by porcine cardiac myosin in Lewis rats. We orally administered a vehicle, various dosages of carvedilol, metoprolol, or propranolol to rats with EAM for 3 weeks. Three beta-blockers decreased heart rates to the same extent. Carvedilol, but not metoprolol or propranolol, markedly reduced the severity of myocarditis at the two different dosages. Only carvedilol decreased the myocardial protein carbonyl contents, and also decreased the myocardial thiobarbituric acid reactive substance products in rats with EAM. Accordingly, carvedilol protects against acute EAM in rats, and this superior cardioprotective effect of carvedilol to metoprolol and propranolol may be due to the antioxidant properties in addition to the hemodynamic modifications. SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/15124928/Cardioprotective_effects_of_carvedilol_on_acute_autoimmune_myocarditis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15124928.ui DB - PRIME DP - Unbound Medicine ER -