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[Comparison of two different vaccination schemes against Hepatitis A and B in Mexican children and adolescents].
Rev Gastroenterol Mex. 2003 Oct-Dec; 68(4):271-6.RG

Abstract

BACKGROUND

Development of multiple antigens in combined vaccines offers the advantages of reducing costs, increasing compliance and provides dual protection. Hepatitis A is an endemic disease in Mexico and hepatitis B, notwithstanding low prevalence, confers risk of progression to cirrhosis, hepatocellular carcinoma, and high medical costs in consequence.

OBJECTIVE

Determine immunogenicity and reactogenicity of a combined vaccine when compared with use of conventional vaccines simultaneously.

METHODS

The present study was a prospective, open, and randomized trial; 73 healthy children and adolescents were included, all with negative serologic markers. They were assigned to one of the following groups: Group 1, combined vaccine (n = 49) Twinrix (HAV 720 UE/HBV 20 micrograms), and group 2, separate vaccines (n = 24) Engerix B 20 micrograms/Havrix 720 UE. Both groups were given two-dose series at months 0 and 6. Geometric titles of antibody production (GMT) anti-HAV and anti-HBV were determined in months 1, 2, 6 and 7. Adverse reactions were registered during the study.

RESULTS

No difference was observed between the two groups in age or gender. Immunogenicity anti-HAV: 100% of vaccines in both groups reached seroprotective levels (> or = 33 mUI/mL). Antibody titles in group 1 were three times higher than those in group 2 (9,696 mIU/mL vs. 3,940 mIU/mL [p = 0.003]) at the end of the study. Immunogenicity anti-HBV: All subjects in both groups reached seroprotective levels (> or = 10 mIU/mL) with similar antibody titles at the end of the study (group 1: 5,603 mIU/mL vs. group 2: 5,201 mIU/mL [p = 0.55 NS]). Reactogenicity: No serious adverse reactions were observed; main were local, and frequency and characteristics were similar in both groups.

CONCLUSIONS

Seroprotective levels and reactogenicity obtained from use of a combined vaccine against hepatitis A/B are acceptable when compared with use of conventional vaccines administered separately.

Authors+Show Affiliations

Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. México. saraigh69@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

spa

PubMed ID

15125329

Citation

González-Huezo, Ma Saraí, et al. "[Comparison of Two Different Vaccination Schemes Against Hepatitis a and B in Mexican Children and Adolescents]." Revista De Gastroenterologia De Mexico, vol. 68, no. 4, 2003, pp. 271-6.
González-Huezo MS, Sánchez-Avila F, García Mayol M, et al. [Comparison of two different vaccination schemes against Hepatitis A and B in Mexican children and adolescents]. Rev Gastroenterol Mex. 2003;68(4):271-6.
González-Huezo, M. S., Sánchez-Avila, F., García Mayol, M., Castro Narro, G., Sixtos, S., Lisker-Melman, M., & Kershenobich, D. (2003). [Comparison of two different vaccination schemes against Hepatitis A and B in Mexican children and adolescents]. Revista De Gastroenterologia De Mexico, 68(4), 271-6.
González-Huezo MS, et al. [Comparison of Two Different Vaccination Schemes Against Hepatitis a and B in Mexican Children and Adolescents]. Rev Gastroenterol Mex. 2003 Oct-Dec;68(4):271-6. PubMed PMID: 15125329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of two different vaccination schemes against Hepatitis A and B in Mexican children and adolescents]. AU - González-Huezo,Ma Saraí, AU - Sánchez-Avila,Francisco, AU - García Mayol,Marcelino, AU - Castro Narro,Graciela, AU - Sixtos,Sara, AU - Lisker-Melman,Mauricio, AU - Kershenobich,David, PY - 2004/5/6/pubmed PY - 2004/6/2/medline PY - 2004/5/6/entrez SP - 271 EP - 6 JF - Revista de gastroenterologia de Mexico JO - Rev Gastroenterol Mex VL - 68 IS - 4 N2 - BACKGROUND: Development of multiple antigens in combined vaccines offers the advantages of reducing costs, increasing compliance and provides dual protection. Hepatitis A is an endemic disease in Mexico and hepatitis B, notwithstanding low prevalence, confers risk of progression to cirrhosis, hepatocellular carcinoma, and high medical costs in consequence. OBJECTIVE: Determine immunogenicity and reactogenicity of a combined vaccine when compared with use of conventional vaccines simultaneously. METHODS: The present study was a prospective, open, and randomized trial; 73 healthy children and adolescents were included, all with negative serologic markers. They were assigned to one of the following groups: Group 1, combined vaccine (n = 49) Twinrix (HAV 720 UE/HBV 20 micrograms), and group 2, separate vaccines (n = 24) Engerix B 20 micrograms/Havrix 720 UE. Both groups were given two-dose series at months 0 and 6. Geometric titles of antibody production (GMT) anti-HAV and anti-HBV were determined in months 1, 2, 6 and 7. Adverse reactions were registered during the study. RESULTS: No difference was observed between the two groups in age or gender. Immunogenicity anti-HAV: 100% of vaccines in both groups reached seroprotective levels (> or = 33 mUI/mL). Antibody titles in group 1 were three times higher than those in group 2 (9,696 mIU/mL vs. 3,940 mIU/mL [p = 0.003]) at the end of the study. Immunogenicity anti-HBV: All subjects in both groups reached seroprotective levels (> or = 10 mIU/mL) with similar antibody titles at the end of the study (group 1: 5,603 mIU/mL vs. group 2: 5,201 mIU/mL [p = 0.55 NS]). Reactogenicity: No serious adverse reactions were observed; main were local, and frequency and characteristics were similar in both groups. CONCLUSIONS: Seroprotective levels and reactogenicity obtained from use of a combined vaccine against hepatitis A/B are acceptable when compared with use of conventional vaccines administered separately. SN - 0375-0906 UR - https://www.unboundmedicine.com/medline/citation/15125329/[Comparison_of_two_different_vaccination_schemes_against_Hepatitis_A_and_B_in_Mexican_children_and_adolescents]_ L2 - https://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -