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Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.
Pharmazie. 2004 Apr; 59(4):294-6.P

Abstract

A new steroidal saponin, dioscoreside E (1), and a known compound, protodioscin (2), were isolated from an ethanol extract of the rhizomes of Dioscorea panthaica. The structure of 1 was established as 3-O-[bis-alpha-L-rhamnopyranosyl-(1 --> 2 and 1 --> 4)-beta-D-glucopyranosyl]-26-O-beta-D-glucopyranosyl-20(R)-methoxy-25(R)-furosta-5,22(23)-diene-3beta,26-diol, on the basis of spectral and chemical evidence. Compounds 1 and 2 showed cytotoxic activity against a panel of tumor cell lines.

Authors+Show Affiliations

Dong M
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Ohio, USA.
Feng XZ
No affiliation info available
Wang BX
No affiliation info available
Ikejima T
No affiliation info available
Wu LJ
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicCell Line, TumorDioscoreaDrug Screening Assays, AntitumorHumansHydrolysisMagnetic Resonance SpectroscopyMiceModels, MolecularMolecular ConformationSaponinsSpectrometry, Mass, Fast Atom BombardmentSteroids

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15125576

Citation

Dong, M, et al. "Steroidal Saponins From Dioscorea Panthaica and Their Cytotoxic Activity." Die Pharmazie, vol. 59, no. 4, 2004, pp. 294-6.
Dong M, Feng XZ, Wang BX, et al. Steroidal saponins from Dioscorea panthaica and their cytotoxic activity. Pharmazie. 2004;59(4):294-6.
Dong, M., Feng, X. Z., Wang, B. X., Ikejima, T., & Wu, L. J. (2004). Steroidal saponins from Dioscorea panthaica and their cytotoxic activity. Die Pharmazie, 59(4), 294-6.
Dong M, et al. Steroidal Saponins From Dioscorea Panthaica and Their Cytotoxic Activity. Pharmazie. 2004;59(4):294-6. PubMed PMID: 15125576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroidal saponins from Dioscorea panthaica and their cytotoxic activity. AU - Dong,M, AU - Feng,X Z, AU - Wang,B X, AU - Ikejima,T, AU - Wu,L J, PY - 2004/5/6/pubmed PY - 2004/6/4/medline PY - 2004/5/6/entrez SP - 294 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 59 IS - 4 N2 - A new steroidal saponin, dioscoreside E (1), and a known compound, protodioscin (2), were isolated from an ethanol extract of the rhizomes of Dioscorea panthaica. The structure of 1 was established as 3-O-[bis-alpha-L-rhamnopyranosyl-(1 --> 2 and 1 --> 4)-beta-D-glucopyranosyl]-26-O-beta-D-glucopyranosyl-20(R)-methoxy-25(R)-furosta-5,22(23)-diene-3beta,26-diol, on the basis of spectral and chemical evidence. Compounds 1 and 2 showed cytotoxic activity against a panel of tumor cell lines. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15125576/Steroidal_saponins_from_Dioscorea_panthaica_and_their_cytotoxic_activity_ DB - PRIME DP - Unbound Medicine ER -