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Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Basic Clin Pharmacol Toxicol. 2004 May; 94(5):232-7.BC

Abstract

In this study we have investigated the effects of administration of procyanidins from grape seeds on serum uric acid levels in a model of hyperuricaemia in mice pretreated with oxonate, as well as the xanthine dehydrogenase and xanthine oxidase activities in mouse liver in vivo. The procyanidins, when orally administered to the oxonate-pretreated hyperuricaemic mice, were able to elicit a dose-dependent hypouricaemic effect. At a dose of 400 mg/kg for 3 days, the serum urate levels of the oxonate-pretreated mice were not different from the normal mice. In addition, the hepatic activities of xanthine dehydrogenase and xanthine oxidase in the procyanidins-treated mice were found to decrease significantly. However, the hypouricaemic effects observed in the experimental animals did not seem to parallel the changes in xanthine dehydrogenase and xanthine oxidase activities, implying that the procyanidins might be acting via other mechanisms apart from simple inhibition of enzyme activities. Furthermore, the procyanidin-treated animals exhibited normal growth while the allopurinol-treated animals exhibited some retarded growth. These results demonstrated for the first time that the procyanidins from grape seeds possess in vivo urate-lowering activities. The potential application of these natural compounds in the treatment of hyperuricaemia is discussed.

Authors+Show Affiliations

Institute of Functional Biomolecule, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15125693

Citation

Wang, Ying, et al. "Administration of Procyanidins From Grape Seeds Reduces Serum Uric Acid Levels and Decreases Hepatic Xanthine Dehydrogenase/oxidase Activities in Oxonate-treated Mice." Basic & Clinical Pharmacology & Toxicology, vol. 94, no. 5, 2004, pp. 232-7.
Wang Y, Zhu JX, Kong LD, et al. Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice. Basic Clin Pharmacol Toxicol. 2004;94(5):232-7.
Wang, Y., Zhu, J. X., Kong, L. D., Yang, C., Cheng, C. H., & Zhang, X. (2004). Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice. Basic & Clinical Pharmacology & Toxicology, 94(5), 232-7.
Wang Y, et al. Administration of Procyanidins From Grape Seeds Reduces Serum Uric Acid Levels and Decreases Hepatic Xanthine Dehydrogenase/oxidase Activities in Oxonate-treated Mice. Basic Clin Pharmacol Toxicol. 2004;94(5):232-7. PubMed PMID: 15125693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice. AU - Wang,Ying, AU - Zhu,Ji Xiao, AU - Kong,Ling Dong, AU - Yang,Cheng, AU - Cheng,Christopher Hon Ki, AU - Zhang,Xin, PY - 2004/5/6/pubmed PY - 2004/9/10/medline PY - 2004/5/6/entrez SP - 232 EP - 7 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 94 IS - 5 N2 - In this study we have investigated the effects of administration of procyanidins from grape seeds on serum uric acid levels in a model of hyperuricaemia in mice pretreated with oxonate, as well as the xanthine dehydrogenase and xanthine oxidase activities in mouse liver in vivo. The procyanidins, when orally administered to the oxonate-pretreated hyperuricaemic mice, were able to elicit a dose-dependent hypouricaemic effect. At a dose of 400 mg/kg for 3 days, the serum urate levels of the oxonate-pretreated mice were not different from the normal mice. In addition, the hepatic activities of xanthine dehydrogenase and xanthine oxidase in the procyanidins-treated mice were found to decrease significantly. However, the hypouricaemic effects observed in the experimental animals did not seem to parallel the changes in xanthine dehydrogenase and xanthine oxidase activities, implying that the procyanidins might be acting via other mechanisms apart from simple inhibition of enzyme activities. Furthermore, the procyanidin-treated animals exhibited normal growth while the allopurinol-treated animals exhibited some retarded growth. These results demonstrated for the first time that the procyanidins from grape seeds possess in vivo urate-lowering activities. The potential application of these natural compounds in the treatment of hyperuricaemia is discussed. SN - 1742-7835 UR - https://www.unboundmedicine.com/medline/citation/15125693/Administration_of_procyanidins_from_grape_seeds_reduces_serum_uric_acid_levels_and_decreases_hepatic_xanthine_dehydrogenase/oxidase_activities_in_oxonate_treated_mice_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1742-7835&date=2004&volume=94&issue=5&spage=232 DB - PRIME DP - Unbound Medicine ER -