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IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.
Diabetes Res Clin Pract. 2004 Jun; 64(3):213-9.DR

Abstract

Previous studies have established that impaired glucose tolerance (IGT) patients with fasting hyperglycemia (IGT/FH: fasting plasma glucose (FPG) level 6.1-7.0 mmol/l and 2 h PG level of 7.8-11.1 mmol/l) exhibit higher insulin resistance than those with isolated IGT (FPG level <6.1 mmol/l and 2 h PG level of 7.8-11.1 mmol/l), but the association with microalbuminuria has not been determined. Here, we evaluate the prevalence of microalbuminuria in non-diabetic Japanese males 20-70 years of age. The subjects were classified into four groups based on the results of OGTT: normal glucose tolerance (NGT: n=71), impaired fasting glucose (IFG: n=24), isolated IGT (n=36), and IGT/FH (n=23). A urinary albumin-to-creatinine ratio (ACR) from 30 to 300 microg/mg creatinine was counted as microalbuminuria. The prevalence of microalbuminuria was higher in subjects with IGT/FH than in subjects with isolated IGT (26% versus 14%). Logistic regression analysis showed microalbuminuria to be more significantly associated with IGT/FH (OR=3.82, 95% CI 1.09-13.36) than with isolated IGT (OR=1.75, 95% CI 0.50-6.17). While insulin resistance (HOMA-IR) in isolated IGT was not significantly different from that in NGT, insulin resistance in IGT/FH was significantly higher (P<0.01). Regression analysis of ACR in IGT showed a significant correlation with insulin resistance (P=0.012). Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance.

Authors+Show Affiliations

Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15126010

Citation

Suzuki, Haruhiko, et al. "IGT With Fasting Hyperglycemia Is More Strongly Associated With Microalbuminuria Than IGT Without Fasting Hyperglycemia." Diabetes Research and Clinical Practice, vol. 64, no. 3, 2004, pp. 213-9.
Suzuki H, Fukushima M, Usami M, et al. IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia. Diabetes Res Clin Pract. 2004;64(3):213-9.
Suzuki, H., Fukushima, M., Usami, M., Ikeda, M., Taniguchi, A., Nakai, Y., Matsuura, T., Yasuda, K., Hosokawa, M., Seino, Y., & Yamada, Y. (2004). IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia. Diabetes Research and Clinical Practice, 64(3), 213-9.
Suzuki H, et al. IGT With Fasting Hyperglycemia Is More Strongly Associated With Microalbuminuria Than IGT Without Fasting Hyperglycemia. Diabetes Res Clin Pract. 2004;64(3):213-9. PubMed PMID: 15126010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia. AU - Suzuki,Haruhiko, AU - Fukushima,Mitsuo, AU - Usami,Masaru, AU - Ikeda,Masaki, AU - Taniguchi,Ataru, AU - Nakai,Yoshikatsu, AU - Matsuura,Toshifumi, AU - Yasuda,Koichiro, AU - Hosokawa,Masaya, AU - Seino,Yutaka, AU - Yamada,Yuichiro, PY - 2003/10/07/revised PY - 2003/11/13/accepted PY - 2004/5/6/pubmed PY - 2004/12/18/medline PY - 2004/5/6/entrez SP - 213 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 64 IS - 3 N2 - Previous studies have established that impaired glucose tolerance (IGT) patients with fasting hyperglycemia (IGT/FH: fasting plasma glucose (FPG) level 6.1-7.0 mmol/l and 2 h PG level of 7.8-11.1 mmol/l) exhibit higher insulin resistance than those with isolated IGT (FPG level <6.1 mmol/l and 2 h PG level of 7.8-11.1 mmol/l), but the association with microalbuminuria has not been determined. Here, we evaluate the prevalence of microalbuminuria in non-diabetic Japanese males 20-70 years of age. The subjects were classified into four groups based on the results of OGTT: normal glucose tolerance (NGT: n=71), impaired fasting glucose (IFG: n=24), isolated IGT (n=36), and IGT/FH (n=23). A urinary albumin-to-creatinine ratio (ACR) from 30 to 300 microg/mg creatinine was counted as microalbuminuria. The prevalence of microalbuminuria was higher in subjects with IGT/FH than in subjects with isolated IGT (26% versus 14%). Logistic regression analysis showed microalbuminuria to be more significantly associated with IGT/FH (OR=3.82, 95% CI 1.09-13.36) than with isolated IGT (OR=1.75, 95% CI 0.50-6.17). While insulin resistance (HOMA-IR) in isolated IGT was not significantly different from that in NGT, insulin resistance in IGT/FH was significantly higher (P<0.01). Regression analysis of ACR in IGT showed a significant correlation with insulin resistance (P=0.012). Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/15126010/IGT_with_fasting_hyperglycemia_is_more_strongly_associated_with_microalbuminuria_than_IGT_without_fasting_hyperglycemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168822703002985 DB - PRIME DP - Unbound Medicine ER -