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Quantitative assessment of structural damage in eyes with localized visual field abnormalities.
Am J Ophthalmol. 2004 May; 137(5):797-805.AJ

Abstract

PURPOSE

To evaluate the pattern of structural damage in the macula and peripapillary retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT) and scanning laser polarimetry (SLP-VCC) in glaucomatous eyes with localized visual field defects.

DESIGN

Prospective, cross-sectional analysis.

METHODS

Complete examination, automated achromatic perimetry (AAP), Stratus OCT imaging (512 A-scans) of the peripapillary retina and macula, and SLP-VCC imaging of the peripapillary RNFL were performed. Thickness values in the retinal segments associated with the visual field defect (glaucomatous segments) were compared with corresponding segments across the horizontal raphe (nonglaucomatous segments) and age-matched normal controls.

RESULTS

Forty eyes of 40 patients (20 normal, 20 glaucomatous) were enrolled (mean age, 71 +/- 10 years; range, 50 to 89). Mean RNFL thickness using SLP-VCC and OCT in the nonglaucomatous segments of glaucomatous eyes (54.0 +/- 9.7 microm, 64.7 +/- 19.0 microm) were significantly (P =.009, <0.0001) reduced compared with the thickness measurements in the corresponding segments of age-matched normal subjects (62.5 +/- 9.2 microm, 105.6 +/- 19.0 microm) respectively. No significant (P =.4) differences in the macular thickness measurements were observed between nonglaucomatous (239.0 +/- 19.4 microm) and normal segments (243.5 +/- 15.0 microm). Compared with age-matched controls, RNFL thickness in the nonglaucomatous segment was abnormal in 15 of 20 patients (75%) with SLP-VCC and in 18 of 20 patients (90%) with OCT. Macular thickness in the nonglaucomatous segment was abnormal in 11 of 20 patients (55%).

CONCLUSIONS

Diffuse RNFL and retinal ganglion cell loss is present in eyes with localized visual field abnormalities. Detection of localized changes in macular thickness is limited by measurement overlap among normal and glaucomatous eyes.

Authors+Show Affiliations

Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15126142

Citation

Bagga, Harmohina, and David S. Greenfield. "Quantitative Assessment of Structural Damage in Eyes With Localized Visual Field Abnormalities." American Journal of Ophthalmology, vol. 137, no. 5, 2004, pp. 797-805.
Bagga H, Greenfield DS. Quantitative assessment of structural damage in eyes with localized visual field abnormalities. Am J Ophthalmol. 2004;137(5):797-805.
Bagga, H., & Greenfield, D. S. (2004). Quantitative assessment of structural damage in eyes with localized visual field abnormalities. American Journal of Ophthalmology, 137(5), 797-805.
Bagga H, Greenfield DS. Quantitative Assessment of Structural Damage in Eyes With Localized Visual Field Abnormalities. Am J Ophthalmol. 2004;137(5):797-805. PubMed PMID: 15126142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative assessment of structural damage in eyes with localized visual field abnormalities. AU - Bagga,Harmohina, AU - Greenfield,David S, PY - 2003/11/12/accepted PY - 2004/5/6/pubmed PY - 2004/6/4/medline PY - 2004/5/6/entrez SP - 797 EP - 805 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 137 IS - 5 N2 - PURPOSE: To evaluate the pattern of structural damage in the macula and peripapillary retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT) and scanning laser polarimetry (SLP-VCC) in glaucomatous eyes with localized visual field defects. DESIGN: Prospective, cross-sectional analysis. METHODS: Complete examination, automated achromatic perimetry (AAP), Stratus OCT imaging (512 A-scans) of the peripapillary retina and macula, and SLP-VCC imaging of the peripapillary RNFL were performed. Thickness values in the retinal segments associated with the visual field defect (glaucomatous segments) were compared with corresponding segments across the horizontal raphe (nonglaucomatous segments) and age-matched normal controls. RESULTS: Forty eyes of 40 patients (20 normal, 20 glaucomatous) were enrolled (mean age, 71 +/- 10 years; range, 50 to 89). Mean RNFL thickness using SLP-VCC and OCT in the nonglaucomatous segments of glaucomatous eyes (54.0 +/- 9.7 microm, 64.7 +/- 19.0 microm) were significantly (P =.009, <0.0001) reduced compared with the thickness measurements in the corresponding segments of age-matched normal subjects (62.5 +/- 9.2 microm, 105.6 +/- 19.0 microm) respectively. No significant (P =.4) differences in the macular thickness measurements were observed between nonglaucomatous (239.0 +/- 19.4 microm) and normal segments (243.5 +/- 15.0 microm). Compared with age-matched controls, RNFL thickness in the nonglaucomatous segment was abnormal in 15 of 20 patients (75%) with SLP-VCC and in 18 of 20 patients (90%) with OCT. Macular thickness in the nonglaucomatous segment was abnormal in 11 of 20 patients (55%). CONCLUSIONS: Diffuse RNFL and retinal ganglion cell loss is present in eyes with localized visual field abnormalities. Detection of localized changes in macular thickness is limited by measurement overlap among normal and glaucomatous eyes. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15126142/Quantitative_assessment_of_structural_damage_in_eyes_with_localized_visual_field_abnormalities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939403014697 DB - PRIME DP - Unbound Medicine ER -