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Visual short-term effects of Viagra: double-blind study in healthy young subjects.
Am J Ophthalmol. 2004 May; 137(5):842-9.AJ

Abstract

PURPOSE

To investigate short-term visual effects of a single 100-mg dose of Viagra (sildenafil citrate) in healthy men.

DESIGN

Randomized, double-blind, placebo-controlled clinical trial of drug effects on normal volunteers conducted by a single center.

METHODS

Twenty men, aged 20 to 40 years, were treated with either a placebo or 100 mg sildenafil. Visual function tests included electroretinogram (ERG) recordings, on-/off- and 3.3 Hz-flicker-ERG recordings, anomaloscope matches, and measurements of cone contrast sensitivities and transient tritanopia.

RESULTS

Most visual tests did not differ between the sildenafil and placebo groups. However, statistically significant increases in sensitivity during transient tritanopia were observed as well as significant prolongations in the implicit times of scotopic a-wave, photopic b-wave, and 3.3 Hz-flicker a-wave and b-wave ERG recordings. The magnitude of the differences correlated with peak sidenafil plasma concentration. Although rod amplitudes of the ERG recordings tended to be higher and cone amplitudes lower in the sildenafil group after drug ingestion, the differences were nonsignificant. There were no reports of visual side effects, and all electrophysiologic and psychophysical measurements returned to the normal range within 24 hours.

CONCLUSIONS

A single oral dose of 100-mg sildenafil given to healthy young men led to small but statistically significant transient changes of outer and inner retinal function, as detected by ERG and psychophysical methods. Although the acute effects were fully reversible within 24 hours, it would be worthwhile to compare them with those induced by other PDE5 and PDE6 inhibitors.

Authors+Show Affiliations

Department of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, Schleichstrasse 12-16, D-72076 Tübingen, Germany. herbert.jaegle@uni-tuebingen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15126148

Citation

Jägle, Herbert, et al. "Visual Short-term Effects of Viagra: Double-blind Study in Healthy Young Subjects." American Journal of Ophthalmology, vol. 137, no. 5, 2004, pp. 842-9.
Jägle H, Jägle C, Sérey L, et al. Visual short-term effects of Viagra: double-blind study in healthy young subjects. Am J Ophthalmol. 2004;137(5):842-9.
Jägle, H., Jägle, C., Sérey, L., Yu, A., Rilk, A., Sadowski, B., Besch, D., Zrenner, E., & Sharpe, L. T. (2004). Visual short-term effects of Viagra: double-blind study in healthy young subjects. American Journal of Ophthalmology, 137(5), 842-9.
Jägle H, et al. Visual Short-term Effects of Viagra: Double-blind Study in Healthy Young Subjects. Am J Ophthalmol. 2004;137(5):842-9. PubMed PMID: 15126148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual short-term effects of Viagra: double-blind study in healthy young subjects. AU - Jägle,Herbert, AU - Jägle,Christine, AU - Sérey,Ludwig, AU - Yu,Alice, AU - Rilk,Albrecht, AU - Sadowski,Bettina, AU - Besch,Dorothea, AU - Zrenner,Eberhart, AU - Sharpe,Lindsay T, PY - 2003/11/26/accepted PY - 2004/5/6/pubmed PY - 2004/6/4/medline PY - 2004/5/6/entrez SP - 842 EP - 9 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 137 IS - 5 N2 - PURPOSE: To investigate short-term visual effects of a single 100-mg dose of Viagra (sildenafil citrate) in healthy men. DESIGN: Randomized, double-blind, placebo-controlled clinical trial of drug effects on normal volunteers conducted by a single center. METHODS: Twenty men, aged 20 to 40 years, were treated with either a placebo or 100 mg sildenafil. Visual function tests included electroretinogram (ERG) recordings, on-/off- and 3.3 Hz-flicker-ERG recordings, anomaloscope matches, and measurements of cone contrast sensitivities and transient tritanopia. RESULTS: Most visual tests did not differ between the sildenafil and placebo groups. However, statistically significant increases in sensitivity during transient tritanopia were observed as well as significant prolongations in the implicit times of scotopic a-wave, photopic b-wave, and 3.3 Hz-flicker a-wave and b-wave ERG recordings. The magnitude of the differences correlated with peak sidenafil plasma concentration. Although rod amplitudes of the ERG recordings tended to be higher and cone amplitudes lower in the sildenafil group after drug ingestion, the differences were nonsignificant. There were no reports of visual side effects, and all electrophysiologic and psychophysical measurements returned to the normal range within 24 hours. CONCLUSIONS: A single oral dose of 100-mg sildenafil given to healthy young men led to small but statistically significant transient changes of outer and inner retinal function, as detected by ERG and psychophysical methods. Although the acute effects were fully reversible within 24 hours, it would be worthwhile to compare them with those induced by other PDE5 and PDE6 inhibitors. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15126148/Visual_short_term_effects_of_Viagra:_double_blind_study_in_healthy_young_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939403015290 DB - PRIME DP - Unbound Medicine ER -