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High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study.

Abstract

This study assessed the association of habitual dietary calcium intake and bone loss in early postmenopausal women. Four hundred fifty-four healthy postmenopausal Chinese women were enrolled for this 18-month cohort study. The subjects were 48-62 yr of age and within 12 yr of natural menopause. Dietary intake was assessed by the food frequency method, and bone mass was measured using dual energy x-ray absorptiometry at baseline and 9 and 18 months. The association between mean habitual dietary intake over the follow-up period and the rate of bone loss was examined. During the 18-month follow-up, the total loss rates of BMD at the whole body, lumber spine, femoral neck, and total hip were 1.28, 0.60, 1.54, and 0.56% (all P < 0.01). Subjects were stratified into four quartiles according to calcium intake during the period of follow-up. Quartiles I-IV had median intakes of 341, 505, 682, and 934 mg Ca/d. Subjects in quartile IV had significantly less BMD loss at the whole body and less BMD/bone mineral content loss at Ward's triangle, even after adjustments for confounding factors (by analysis of covariance). Multiple linear regression analyses showed significant positive associations between calcium intake and BMD change at the whole body (P = 0.006) and Ward's triangle (P = 0.021). Calcium intake was significantly associated with bone mineral content change at the trochanter (P = 0.025) and Ward's triangle (P < 0.001). No significant effect of calcium intake at the spine was found. In conclusion, habitual dietary calcium intake had a beneficial effect on bone loss at the whole body and some regions of the hip. Our findings suggest that an intake exceeding 900 mg calcium/d was helpful in the prevention of cortical bone loss among early postmenopausal Chinese women.

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  • Authors+Show Affiliations

    ,

    Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. suzanneho@cuhk.edu.hk

    , ,

    Source

    MeSH

    Bone Density
    Calcium, Dietary
    Cohort Studies
    Dose-Response Relationship, Drug
    Female
    Follow-Up Studies
    Humans
    Linear Models
    Middle Aged
    Osteoporosis, Postmenopausal
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15126537

    Citation

    Ho, Suzanne C., et al. "High Habitual Calcium Intake Attenuates Bone Loss in Early Postmenopausal Chinese Women: an 18-month Follow-up Study." The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 5, 2004, pp. 2166-70.
    Ho SC, Chen YM, Woo JL, et al. High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study. J Clin Endocrinol Metab. 2004;89(5):2166-70.
    Ho, S. C., Chen, Y. M., Woo, J. L., & Lam, S. S. (2004). High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study. The Journal of Clinical Endocrinology and Metabolism, 89(5), pp. 2166-70.
    Ho SC, et al. High Habitual Calcium Intake Attenuates Bone Loss in Early Postmenopausal Chinese Women: an 18-month Follow-up Study. J Clin Endocrinol Metab. 2004;89(5):2166-70. PubMed PMID: 15126537.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women: an 18-month follow-up study. AU - Ho,Suzanne C, AU - Chen,Yu-Ming, AU - Woo,Jean L F, AU - Lam,Silvia S H, PY - 2004/5/6/pubmed PY - 2004/7/15/medline PY - 2004/5/6/entrez SP - 2166 EP - 70 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 89 IS - 5 N2 - This study assessed the association of habitual dietary calcium intake and bone loss in early postmenopausal women. Four hundred fifty-four healthy postmenopausal Chinese women were enrolled for this 18-month cohort study. The subjects were 48-62 yr of age and within 12 yr of natural menopause. Dietary intake was assessed by the food frequency method, and bone mass was measured using dual energy x-ray absorptiometry at baseline and 9 and 18 months. The association between mean habitual dietary intake over the follow-up period and the rate of bone loss was examined. During the 18-month follow-up, the total loss rates of BMD at the whole body, lumber spine, femoral neck, and total hip were 1.28, 0.60, 1.54, and 0.56% (all P < 0.01). Subjects were stratified into four quartiles according to calcium intake during the period of follow-up. Quartiles I-IV had median intakes of 341, 505, 682, and 934 mg Ca/d. Subjects in quartile IV had significantly less BMD loss at the whole body and less BMD/bone mineral content loss at Ward's triangle, even after adjustments for confounding factors (by analysis of covariance). Multiple linear regression analyses showed significant positive associations between calcium intake and BMD change at the whole body (P = 0.006) and Ward's triangle (P = 0.021). Calcium intake was significantly associated with bone mineral content change at the trochanter (P = 0.025) and Ward's triangle (P < 0.001). No significant effect of calcium intake at the spine was found. In conclusion, habitual dietary calcium intake had a beneficial effect on bone loss at the whole body and some regions of the hip. Our findings suggest that an intake exceeding 900 mg calcium/d was helpful in the prevention of cortical bone loss among early postmenopausal Chinese women. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15126537/High_habitual_calcium_intake_attenuates_bone_loss_in_early_postmenopausal_Chinese_women:_an_18_month_follow_up_study_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2003-031338 DB - PRIME DP - Unbound Medicine ER -