Tags

Type your tag names separated by a space and hit enter

Penicillin and macrolide resistance in pneumococcal pneumonia: does in vitro resistance affect clinical outcomes?
Clin Infect Dis. 2004 May 15; 38 Suppl 4:S346-9.CI

Abstract

In vitro resistance to antimicrobial agents is escalating among pathogens responsible for the most serious respiratory tract infections. Some reports have suggested that this has direct clinical implications. Because of penicillin and macrolide resistance in Streptococcus pneumoniae, current guidelines for the initial treatment of respiratory tract infections advocate less reliance on the use of either of these classes of drugs in single-agent therapy. Recent studies that have assessed the impact of beta -lactam and macrolide resistance on clinical outcomes in community-acquired pneumonia fail to provide incontrovertible evidence for a direct link between in vitro resistance and treatment failure. However, there are anecdotal reports of breakthrough bacteremia due to macrolide-resistant pneumococci among patients receiving macrolide therapy, unlike the situation for beta -lactams and penicillin-resistant pneumococci. Continued efforts, including in vitro surveillance, appropriate antibiotic use campaigns, and immunization programs, will be important in limiting the spread of drug-resistant S. pneumoniae.

Authors+Show Affiliations

Pfizer, New York, New York 10017, USA. constance.rothermel@pfizer.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15127368

Citation

Rothermel, Constance D.. "Penicillin and Macrolide Resistance in Pneumococcal Pneumonia: Does in Vitro Resistance Affect Clinical Outcomes?" Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 38 Suppl 4, 2004, pp. S346-9.
Rothermel CD. Penicillin and macrolide resistance in pneumococcal pneumonia: does in vitro resistance affect clinical outcomes? Clin Infect Dis. 2004;38 Suppl 4:S346-9.
Rothermel, C. D. (2004). Penicillin and macrolide resistance in pneumococcal pneumonia: does in vitro resistance affect clinical outcomes? Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 38 Suppl 4, S346-9.
Rothermel CD. Penicillin and Macrolide Resistance in Pneumococcal Pneumonia: Does in Vitro Resistance Affect Clinical Outcomes. Clin Infect Dis. 2004 May 15;38 Suppl 4:S346-9. PubMed PMID: 15127368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Penicillin and macrolide resistance in pneumococcal pneumonia: does in vitro resistance affect clinical outcomes? A1 - Rothermel,Constance D, PY - 2004/5/6/pubmed PY - 2004/6/17/medline PY - 2004/5/6/entrez SP - S346 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 38 Suppl 4 N2 - In vitro resistance to antimicrobial agents is escalating among pathogens responsible for the most serious respiratory tract infections. Some reports have suggested that this has direct clinical implications. Because of penicillin and macrolide resistance in Streptococcus pneumoniae, current guidelines for the initial treatment of respiratory tract infections advocate less reliance on the use of either of these classes of drugs in single-agent therapy. Recent studies that have assessed the impact of beta -lactam and macrolide resistance on clinical outcomes in community-acquired pneumonia fail to provide incontrovertible evidence for a direct link between in vitro resistance and treatment failure. However, there are anecdotal reports of breakthrough bacteremia due to macrolide-resistant pneumococci among patients receiving macrolide therapy, unlike the situation for beta -lactams and penicillin-resistant pneumococci. Continued efforts, including in vitro surveillance, appropriate antibiotic use campaigns, and immunization programs, will be important in limiting the spread of drug-resistant S. pneumoniae. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15127368/Penicillin_and_macrolide_resistance_in_pneumococcal_pneumonia:_does_in_vitro_resistance_affect_clinical_outcomes L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/382691 DB - PRIME DP - Unbound Medicine ER -