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Posterior capsule opacification after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM lenses: one-year results of an intraindividual comparison multicenter study.
J Cataract Refract Surg. 2004 May; 30(5):978-85.JC

Abstract

PURPOSE

To perform an intraindividual comparison of posterior capsule opacification (PCO) with 2 foldable intraocular lenses (IOLs) and a foldable acrylic IOL 1 year after in-the-bag implantation.

SETTINGS

Seven German ophthalmology centers.

METHODS

In an open prospective randomized multicenter study, each center intraindividually compared a high-refractive-index, sharp-edged optic silicone IOL (CeeOn Edge 911A, Pharmacia) with a high-refractive-index, round-edged optic silicone IOL (PhacoFlex SI-40NB, Allergan) or a sharp-edged optic acrylic IOL (AcrySof MA60BM, Alcon). Of 288 randomized patients, 247 had standard phacoemulsification with in-the-bag IOL implantation in both eyes by the same surgeon. One eye of each patient received a CeeOn Edge IOL and the fellow eye, an AcrySof or PhacoFlex IOL. A morphologic evaluation of PCO was performed using the Evaluation of Posterior Capsule Opacification (EPCO) system 1 to 2 weeks and 11 to 14 months after surgery. The digital pictures were evaluated by an independent investigator who was blind to the type of IOL. Intraindividual differences in EPCO scores were statistically evaluated by a 1-sided binomial test at an alpha-level of 5%.

RESULTS

One year after surgery, 127 patients with the AcrySof IOL and 102 patients with the PhacoFlex IOL in the control eye were reexamined. Functional results, safety, and handling were not significantly different between the 3 IOLs. All reexamined eyes had a very low PCO grade. The EPCO values revealed less PCO in eyes with the CeeOn Edge IOL than in eyes with the AcrySof or PhacoFlex IOL, but the difference was not statistically significant. A neodymium:YAG laser capsulotomy was performed in 1 eye with a CeeOn Edge IOL, 1 eye with an AcrySof IOL, and 2 eyes with a PhacoFlex IOL.

CONCLUSIONS

The EPCO PCO grade was low 1 year after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM IOLs; there was no statistically significant difference between the IOLs. The impact of IOL material and edge design on PCO development might be relevant in a long-term follow-up of this study.

Authors+Show Affiliations

Department of Ophthalmology, Bundesknappschaft's Hospital, Sulzbach, Germany. Mester@kksulzbach.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15130632

Citation

Mester, Ulrich, et al. "Posterior Capsule Opacification After Implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM Lenses: One-year Results of an Intraindividual Comparison Multicenter Study." Journal of Cataract and Refractive Surgery, vol. 30, no. 5, 2004, pp. 978-85.
Mester U, Fabian E, Gerl R, et al. Posterior capsule opacification after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM lenses: one-year results of an intraindividual comparison multicenter study. J Cataract Refract Surg. 2004;30(5):978-85.
Mester, U., Fabian, E., Gerl, R., Hunold, W., Hütz, W., Strobel, J., Hoyer, H., & Kohnen, T. (2004). Posterior capsule opacification after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM lenses: one-year results of an intraindividual comparison multicenter study. Journal of Cataract and Refractive Surgery, 30(5), 978-85.
Mester U, et al. Posterior Capsule Opacification After Implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM Lenses: One-year Results of an Intraindividual Comparison Multicenter Study. J Cataract Refract Surg. 2004;30(5):978-85. PubMed PMID: 15130632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posterior capsule opacification after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM lenses: one-year results of an intraindividual comparison multicenter study. AU - Mester,Ulrich, AU - Fabian,Ekkehard, AU - Gerl,Ralf, AU - Hunold,Wilfried, AU - Hütz,Werner, AU - Strobel,Jürgen, AU - Hoyer,Heike, AU - Kohnen,Thomas, PY - 2003/09/10/accepted PY - 2004/5/8/pubmed PY - 2004/6/24/medline PY - 2004/5/8/entrez SP - 978 EP - 85 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 30 IS - 5 N2 - PURPOSE: To perform an intraindividual comparison of posterior capsule opacification (PCO) with 2 foldable intraocular lenses (IOLs) and a foldable acrylic IOL 1 year after in-the-bag implantation. SETTINGS: Seven German ophthalmology centers. METHODS: In an open prospective randomized multicenter study, each center intraindividually compared a high-refractive-index, sharp-edged optic silicone IOL (CeeOn Edge 911A, Pharmacia) with a high-refractive-index, round-edged optic silicone IOL (PhacoFlex SI-40NB, Allergan) or a sharp-edged optic acrylic IOL (AcrySof MA60BM, Alcon). Of 288 randomized patients, 247 had standard phacoemulsification with in-the-bag IOL implantation in both eyes by the same surgeon. One eye of each patient received a CeeOn Edge IOL and the fellow eye, an AcrySof or PhacoFlex IOL. A morphologic evaluation of PCO was performed using the Evaluation of Posterior Capsule Opacification (EPCO) system 1 to 2 weeks and 11 to 14 months after surgery. The digital pictures were evaluated by an independent investigator who was blind to the type of IOL. Intraindividual differences in EPCO scores were statistically evaluated by a 1-sided binomial test at an alpha-level of 5%. RESULTS: One year after surgery, 127 patients with the AcrySof IOL and 102 patients with the PhacoFlex IOL in the control eye were reexamined. Functional results, safety, and handling were not significantly different between the 3 IOLs. All reexamined eyes had a very low PCO grade. The EPCO values revealed less PCO in eyes with the CeeOn Edge IOL than in eyes with the AcrySof or PhacoFlex IOL, but the difference was not statistically significant. A neodymium:YAG laser capsulotomy was performed in 1 eye with a CeeOn Edge IOL, 1 eye with an AcrySof IOL, and 2 eyes with a PhacoFlex IOL. CONCLUSIONS: The EPCO PCO grade was low 1 year after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM IOLs; there was no statistically significant difference between the IOLs. The impact of IOL material and edge design on PCO development might be relevant in a long-term follow-up of this study. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/15130632/Posterior_capsule_opacification_after_implantation_of_CeeOn_Edge_911A_PhacoFlex_SI_40NB_and_AcrySof_MA60BM_lenses:_one_year_results_of_an_intraindividual_comparison_multicenter_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0886335003009313 DB - PRIME DP - Unbound Medicine ER -