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Capsular bag opacification after experimental implantation of a new accommodating intraocular lens in rabbit eyes.
J Cataract Refract Surg. 2004 May; 30(5):1114-23.JC

Abstract

PURPOSE

To evaluate the development of capsular bag opacification in rabbit eyes after implantation of an intraocular lens (IOL) designed to minimize contact between the anterior capsule and the IOL and ensure expansion of the capsular bag.

SETTING

David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

METHODS

Ten New Zealand white rabbits had a study IOL (new accommodating silicone IOL [Synchrony, Visiogen, Inc.]) implanted in 1 eye and a control IOL (1-piece plate silicone IOL with large fixation holes) implanted in the other eye. Intraocular lens position, anterior capsule opacification (ACO), and posterior capsule opacification (PCO) were qualitatively assessed using slitlamp retroillumination photographs of the dilated eyes. Anterior capsule opacification and PCO were graded on a 0 to 4 scale after the eyes were enucleated (Miyake-Apple posterior and anterior views after excision of the cornea and iris). The eyes were also evaluated histopathologically.

RESULTS

The rate of ACO and PCO was significantly higher in the control group. Fibrosis and ACO were almost absent in the study group; the control group exhibited extensive capsulorhexis contraction, including capsulorhexis occlusion. Postoperative IOL dislocation into the anterior chamber and pupillary block syndrome were observed in some eyes in the study group.

CONCLUSIONS

The special design features associated with the study IOL appeared to help prevent PCO. Complications in the study group were probably caused by the increased posterior vitreous pressure in rabbit eyes compared to human eyes and the relatively large size of the study IOL relative to the anterior segment of rabbit eyes.

Authors+Show Affiliations

David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. liliana.werner@hsc.utah.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15130653

Citation

Werner, Liliana, et al. "Capsular Bag Opacification After Experimental Implantation of a New Accommodating Intraocular Lens in Rabbit Eyes." Journal of Cataract and Refractive Surgery, vol. 30, no. 5, 2004, pp. 1114-23.
Werner L, Pandey SK, Izak AM, et al. Capsular bag opacification after experimental implantation of a new accommodating intraocular lens in rabbit eyes. J Cataract Refract Surg. 2004;30(5):1114-23.
Werner, L., Pandey, S. K., Izak, A. M., Vargas, L. G., Trivedi, R. H., Apple, D. J., & Mamalis, N. (2004). Capsular bag opacification after experimental implantation of a new accommodating intraocular lens in rabbit eyes. Journal of Cataract and Refractive Surgery, 30(5), 1114-23.
Werner L, et al. Capsular Bag Opacification After Experimental Implantation of a New Accommodating Intraocular Lens in Rabbit Eyes. J Cataract Refract Surg. 2004;30(5):1114-23. PubMed PMID: 15130653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capsular bag opacification after experimental implantation of a new accommodating intraocular lens in rabbit eyes. AU - Werner,Liliana, AU - Pandey,Suresh K, AU - Izak,Andrea M, AU - Vargas,Luis G, AU - Trivedi,Rupal H, AU - Apple,David J, AU - Mamalis,Nick, PY - 2003/09/09/accepted PY - 2004/5/8/pubmed PY - 2004/6/24/medline PY - 2004/5/8/entrez SP - 1114 EP - 23 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 30 IS - 5 N2 - PURPOSE: To evaluate the development of capsular bag opacification in rabbit eyes after implantation of an intraocular lens (IOL) designed to minimize contact between the anterior capsule and the IOL and ensure expansion of the capsular bag. SETTING: David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: Ten New Zealand white rabbits had a study IOL (new accommodating silicone IOL [Synchrony, Visiogen, Inc.]) implanted in 1 eye and a control IOL (1-piece plate silicone IOL with large fixation holes) implanted in the other eye. Intraocular lens position, anterior capsule opacification (ACO), and posterior capsule opacification (PCO) were qualitatively assessed using slitlamp retroillumination photographs of the dilated eyes. Anterior capsule opacification and PCO were graded on a 0 to 4 scale after the eyes were enucleated (Miyake-Apple posterior and anterior views after excision of the cornea and iris). The eyes were also evaluated histopathologically. RESULTS: The rate of ACO and PCO was significantly higher in the control group. Fibrosis and ACO were almost absent in the study group; the control group exhibited extensive capsulorhexis contraction, including capsulorhexis occlusion. Postoperative IOL dislocation into the anterior chamber and pupillary block syndrome were observed in some eyes in the study group. CONCLUSIONS: The special design features associated with the study IOL appeared to help prevent PCO. Complications in the study group were probably caused by the increased posterior vitreous pressure in rabbit eyes compared to human eyes and the relatively large size of the study IOL relative to the anterior segment of rabbit eyes. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/15130653/Capsular_bag_opacification_after_experimental_implantation_of_a_new_accommodating_intraocular_lens_in_rabbit_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0886335003009064 DB - PRIME DP - Unbound Medicine ER -