Tags

Type your tag names separated by a space and hit enter

Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity.
J Clin Microbiol. 2004 May; 42(5):2239-40.JC

Abstract

Immunochromatographic test (ICT) kits for the rapid detection of immunoglobulin G (IgG) and IgM antibodies to Burkholderia pseudomallei were compared to the indirect hemagglutination (IHA) assay. In 138 culture-confirmed melioidosis cases, sensitivities were 80, 77, and 88% for IHA, ICT IgG, and ICT IgM, respectively. In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100%. ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic.

Authors+Show Affiliations

Menzies School of Health Research, Charles Darwin University, and Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15131200

Citation

O'Brien, Mathew, et al. "Further Evaluation of a Rapid Diagnostic Test for Melioidosis in an Area of Endemicity." Journal of Clinical Microbiology, vol. 42, no. 5, 2004, pp. 2239-40.
O'Brien M, Freeman K, Lum G, et al. Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. J Clin Microbiol. 2004;42(5):2239-40.
O'Brien, M., Freeman, K., Lum, G., Cheng, A. C., Jacups, S. P., & Currie, B. J. (2004). Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. Journal of Clinical Microbiology, 42(5), 2239-40.
O'Brien M, et al. Further Evaluation of a Rapid Diagnostic Test for Melioidosis in an Area of Endemicity. J Clin Microbiol. 2004;42(5):2239-40. PubMed PMID: 15131200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. AU - O'Brien,Mathew, AU - Freeman,Kevin, AU - Lum,Gary, AU - Cheng,Allen C, AU - Jacups,Susan P, AU - Currie,Bart J, PY - 2004/5/8/pubmed PY - 2004/9/3/medline PY - 2004/5/8/entrez SP - 2239 EP - 40 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 42 IS - 5 N2 - Immunochromatographic test (ICT) kits for the rapid detection of immunoglobulin G (IgG) and IgM antibodies to Burkholderia pseudomallei were compared to the indirect hemagglutination (IHA) assay. In 138 culture-confirmed melioidosis cases, sensitivities were 80, 77, and 88% for IHA, ICT IgG, and ICT IgM, respectively. In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100%. ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/15131200/Further_evaluation_of_a_rapid_diagnostic_test_for_melioidosis_in_an_area_of_endemicity_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=15131200 DB - PRIME DP - Unbound Medicine ER -