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[Clinical characteristics and outcome of adult diabetic patients with ketosis as the initial manifestation: a follow-up study].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 May; 16(5):299-302.ZW

Abstract

OBJECTIVE

To study the clinical characteristics and natural history of adult diabetic patients with ketosis as the initial manifestation.

METHODS

In 60 patients with ketosis as the initial symptom, the mean age was (42.78+/-11.14) years and body mass index(BMI) was (2.34+/-3.47) kg/m2. The islet cell antibody (ICA), anti-glutamic acid decarboxylase (GAD) antibody, fast plasma glucose and insulin level, glucose and insulin level of 2 hours after oral glucose test were measured. After insulin therapy, these patients received therapy plan according to their glucose level. During follow-up period, these items were tested again.

RESULTS

There were 27 patients using insulin and 33 patients using diet or oral hypoglycemic drugs for controlling blood glucose during the follow-up. Compared with patients using insulin therapy, patients using oral hypoglycemic drugs or diet therapy showed higher BMI (at onset of ketosis (25.69+/-2.66) kg/m2 vs. (22.64+/-3.75) kg/m2, P=0.001; during follow-up period (26.19+/-3.11) kg/m2 vs. (22.29+/-2.97) kg/m2, P=0.000), higher post-load serum insulin level (at onset of ketosis (32.39+/-35.87) mU/L vs. (18.53+/-14.43) mU/L, P=0.017; during follow-up period (67.34+/-68.42) mU/L vs. (36.40+/-45.39) mU/L, P=0.004), lower HbA 1C (at onset of ketosis (10.76+/-1.25) percent vs. (12.04+/-1.99) percent, P=0.006; during follow-up period (6.97+/-1.31)percent vs. (9.36+/-3.18) percent, P=0.000), higher percentage of ICA and GAD positivity (at onset of ketosis, ICA positive rate was 18.52 percent vs. 0, P=0.030, GAD positive rate was 18.52 percent vs. 0, P=0.030; during follow-up period, ICA positive rate was 7.41 percent vs. 0, P=0.111, GAD positive rate was 14.81 percent vs. 0, P=0.022).

CONCLUSION

Among the adult diabetic patients with ketosis as the first symptom, quite a number of patients are not insulin dependent for the long-term blood sugar control. Ketosis is not a good index for differentiating type 1 from type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, People's Hospital, Peking University, Beijing 100044, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15132798

Citation

Cai, Xiao-ling, and Li-nong Ji. "[Clinical Characteristics and Outcome of Adult Diabetic Patients With Ketosis as the Initial Manifestation: a Follow-up Study]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 16, no. 5, 2004, pp. 299-302.
Cai XL, Ji LN. [Clinical characteristics and outcome of adult diabetic patients with ketosis as the initial manifestation: a follow-up study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004;16(5):299-302.
Cai, X. L., & Ji, L. N. (2004). [Clinical characteristics and outcome of adult diabetic patients with ketosis as the initial manifestation: a follow-up study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 16(5), 299-302.
Cai XL, Ji LN. [Clinical Characteristics and Outcome of Adult Diabetic Patients With Ketosis as the Initial Manifestation: a Follow-up Study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004;16(5):299-302. PubMed PMID: 15132798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical characteristics and outcome of adult diabetic patients with ketosis as the initial manifestation: a follow-up study]. AU - Cai,Xiao-ling, AU - Ji,Li-nong, PY - 2004/5/11/pubmed PY - 2004/11/13/medline PY - 2004/5/11/entrez SP - 299 EP - 302 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 16 IS - 5 N2 - OBJECTIVE: To study the clinical characteristics and natural history of adult diabetic patients with ketosis as the initial manifestation. METHODS: In 60 patients with ketosis as the initial symptom, the mean age was (42.78+/-11.14) years and body mass index(BMI) was (2.34+/-3.47) kg/m2. The islet cell antibody (ICA), anti-glutamic acid decarboxylase (GAD) antibody, fast plasma glucose and insulin level, glucose and insulin level of 2 hours after oral glucose test were measured. After insulin therapy, these patients received therapy plan according to their glucose level. During follow-up period, these items were tested again. RESULTS: There were 27 patients using insulin and 33 patients using diet or oral hypoglycemic drugs for controlling blood glucose during the follow-up. Compared with patients using insulin therapy, patients using oral hypoglycemic drugs or diet therapy showed higher BMI (at onset of ketosis (25.69+/-2.66) kg/m2 vs. (22.64+/-3.75) kg/m2, P=0.001; during follow-up period (26.19+/-3.11) kg/m2 vs. (22.29+/-2.97) kg/m2, P=0.000), higher post-load serum insulin level (at onset of ketosis (32.39+/-35.87) mU/L vs. (18.53+/-14.43) mU/L, P=0.017; during follow-up period (67.34+/-68.42) mU/L vs. (36.40+/-45.39) mU/L, P=0.004), lower HbA 1C (at onset of ketosis (10.76+/-1.25) percent vs. (12.04+/-1.99) percent, P=0.006; during follow-up period (6.97+/-1.31)percent vs. (9.36+/-3.18) percent, P=0.000), higher percentage of ICA and GAD positivity (at onset of ketosis, ICA positive rate was 18.52 percent vs. 0, P=0.030, GAD positive rate was 18.52 percent vs. 0, P=0.030; during follow-up period, ICA positive rate was 7.41 percent vs. 0, P=0.111, GAD positive rate was 14.81 percent vs. 0, P=0.022). CONCLUSION: Among the adult diabetic patients with ketosis as the first symptom, quite a number of patients are not insulin dependent for the long-term blood sugar control. Ketosis is not a good index for differentiating type 1 from type 2 diabetes. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/15132798/[Clinical_characteristics_and_outcome_of_adult_diabetic_patients_with_ketosis_as_the_initial_manifestation:_a_follow_up_study]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -