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Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage.
Acta Pharmacol Sin. 2004 May; 25(5):685-90.AP

Abstract

AIM

To investigate the expression features of PDCD5 (programmed cell death 5 protein) in osteoarthritic and normal human cartilage, and speculate on its potential functions in the pathogenesis of osteoarthritis (OA).

METHODS

Articular cartilage specimens were obtained from 30 patients with OA and 16 healthy patients at the time of arthroplasty. Expression of PDCD5 was detected by flow cytometry, immunofluorescence, RT-PCR and immunohistochemical analysis.

RESULTS

Enhanced expression and nuclear accumulation of PDCD5 in OA chondrocytes were found. PDCD5-positive chondrocytes were mainly distributed in the superficial and deep zones of OA tissue sections, as opposed to, in the superficial and middle regions of normal healthy tissue sections.

CONCLUSION

Since apoptotic chondrocyte death occurs more frequently in OA cartilage than in normal healthy cartilage and PDCD5 is an apoptosis-related protein, the different expression patterns of PDCD5 in OA cartilage from that in normal healthy cartilage indicate that PDCD5 is involved in the pathogenesis of OA.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Third Hospital, Peking University, Beijing 100083, China. A.Cheng@dundee.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15132838

Citation

Cheng, Ai-xin, et al. "Expression of PDCD5, a Novel Apoptosis Related Protein, in Human Osteoarthritic Cartilage." Acta Pharmacologica Sinica, vol. 25, no. 5, 2004, pp. 685-90.
Cheng AX, Lou SQ, Zhou HW, et al. Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage. Acta Pharmacol Sin. 2004;25(5):685-90.
Cheng, A. X., Lou, S. Q., Zhou, H. W., Wang, Y., & Ma, D. L. (2004). Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage. Acta Pharmacologica Sinica, 25(5), 685-90.
Cheng AX, et al. Expression of PDCD5, a Novel Apoptosis Related Protein, in Human Osteoarthritic Cartilage. Acta Pharmacol Sin. 2004;25(5):685-90. PubMed PMID: 15132838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage. AU - Cheng,Ai-xin, AU - Lou,Si-quan, AU - Zhou,Hao-wei, AU - Wang,Ying, AU - Ma,Da-long, PY - 2004/5/11/pubmed PY - 2004/8/11/medline PY - 2004/5/11/entrez SP - 685 EP - 90 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 25 IS - 5 N2 - AIM: To investigate the expression features of PDCD5 (programmed cell death 5 protein) in osteoarthritic and normal human cartilage, and speculate on its potential functions in the pathogenesis of osteoarthritis (OA). METHODS: Articular cartilage specimens were obtained from 30 patients with OA and 16 healthy patients at the time of arthroplasty. Expression of PDCD5 was detected by flow cytometry, immunofluorescence, RT-PCR and immunohistochemical analysis. RESULTS: Enhanced expression and nuclear accumulation of PDCD5 in OA chondrocytes were found. PDCD5-positive chondrocytes were mainly distributed in the superficial and deep zones of OA tissue sections, as opposed to, in the superficial and middle regions of normal healthy tissue sections. CONCLUSION: Since apoptotic chondrocyte death occurs more frequently in OA cartilage than in normal healthy cartilage and PDCD5 is an apoptosis-related protein, the different expression patterns of PDCD5 in OA cartilage from that in normal healthy cartilage indicate that PDCD5 is involved in the pathogenesis of OA. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/15132838/Expression_of_PDCD5_a_novel_apoptosis_related_protein_in_human_osteoarthritic_cartilage_ L2 - http://www.chinaphar.com/1671-4083/25/685.pdf DB - PRIME DP - Unbound Medicine ER -