Tags

Type your tag names separated by a space and hit enter

Long-term virological response to multiple sequential regimens of highly active antiretroviral therapy for HIV infection.
Antivir Ther 2004; 9(2):263-74AT

Abstract

OBJECTIVE

Information about the virological response to sequential highly active antiretroviral therapy (HAART) for HIV infection is limited. The virological response to four consecutive therapies was evaluated in the Swiss HIV Cohort.

DESIGN

Retrospective analysis in an observational cohort.

METHODS

1140 individuals receiving uninterrupted HAART for 4.8 +/- 0.6 years were included. The virological response was classified as success (<400 copies/ml), low-level (LF: 400-5000 copies/ml) or high-level failure (HF: >5000 copies/ml). Potential determinants of the virological response, including patient demographics, treatment history and virological response to previous HAART regimens were analysed using survival and logistic regression analyses.

RESULTS

40.1% failed virologically on the first (22.0% LF; 18.1% HF), 35.1% on the second (14.2% LF; 20.9% HF), 34.2% on the third (9.9% LF; 24.3% HF) and 32.7% on the fourth HAART regimen (9% LF; 23.7% HF). Nucleoside pre-treatment (OR: 2.34; 95% CI: 1.67-3.29) and low baseline CD4 T-cell count (OR: 0.79/100 cells rise; 95% CI: 0.72-0.88) increased the risk of HF on the first HAART. Virological failure on HAART with HIV-1 RNA levels exceeding 1000 copies/ml predicted a poor virological response to subsequent HAART regimens. A switch from a protease inhibitor- to a non-nucleoside reverse transcriptase inhibitor-containing regimen significantly reduced the risk of HF. Multiple switches of HAART did not affect the recovery of CD4 T lymphocytes.

CONCLUSION

Multiple sequential HAART regimens do not per se reduce the likelihood of long-term virological suppression and immunological recovery. However, early virological failure increases significantly the risk of subsequent unfavourable virological responses. The choice of a potent initial antiretroviral drug regimen is therefore critical.

Authors+Show Affiliations

Division of Infectious Diseases, University Hospital, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15134189

Citation

Kaufmann, Gilbert R., et al. "Long-term Virological Response to Multiple Sequential Regimens of Highly Active Antiretroviral Therapy for HIV Infection." Antiviral Therapy, vol. 9, no. 2, 2004, pp. 263-74.
Kaufmann GR, Khanna N, Weber R, et al. Long-term virological response to multiple sequential regimens of highly active antiretroviral therapy for HIV infection. Antivir Ther (Lond). 2004;9(2):263-74.
Kaufmann, G. R., Khanna, N., Weber, R., Perrin, L., Furrer, H., Cavassini, M., ... Battegay, M. (2004). Long-term virological response to multiple sequential regimens of highly active antiretroviral therapy for HIV infection. Antiviral Therapy, 9(2), pp. 263-74.
Kaufmann GR, et al. Long-term Virological Response to Multiple Sequential Regimens of Highly Active Antiretroviral Therapy for HIV Infection. Antivir Ther (Lond). 2004;9(2):263-74. PubMed PMID: 15134189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term virological response to multiple sequential regimens of highly active antiretroviral therapy for HIV infection. AU - Kaufmann,Gilbert R, AU - Khanna,Nina, AU - Weber,Rainer, AU - Perrin,Luc, AU - Furrer,Hansjakob, AU - Cavassini,Matthias, AU - Ledergerber,Bruno, AU - Vernazza,Pietro, AU - Bernasconi,Enos, AU - Rickenbach,Martin, AU - Hirschel,Bernard, AU - Battegay,Manuel, AU - ,, PY - 2004/5/12/pubmed PY - 2004/6/29/medline PY - 2004/5/12/entrez SP - 263 EP - 74 JF - Antiviral therapy JO - Antivir. Ther. (Lond.) VL - 9 IS - 2 N2 - OBJECTIVE: Information about the virological response to sequential highly active antiretroviral therapy (HAART) for HIV infection is limited. The virological response to four consecutive therapies was evaluated in the Swiss HIV Cohort. DESIGN: Retrospective analysis in an observational cohort. METHODS: 1140 individuals receiving uninterrupted HAART for 4.8 +/- 0.6 years were included. The virological response was classified as success (<400 copies/ml), low-level (LF: 400-5000 copies/ml) or high-level failure (HF: >5000 copies/ml). Potential determinants of the virological response, including patient demographics, treatment history and virological response to previous HAART regimens were analysed using survival and logistic regression analyses. RESULTS: 40.1% failed virologically on the first (22.0% LF; 18.1% HF), 35.1% on the second (14.2% LF; 20.9% HF), 34.2% on the third (9.9% LF; 24.3% HF) and 32.7% on the fourth HAART regimen (9% LF; 23.7% HF). Nucleoside pre-treatment (OR: 2.34; 95% CI: 1.67-3.29) and low baseline CD4 T-cell count (OR: 0.79/100 cells rise; 95% CI: 0.72-0.88) increased the risk of HF on the first HAART. Virological failure on HAART with HIV-1 RNA levels exceeding 1000 copies/ml predicted a poor virological response to subsequent HAART regimens. A switch from a protease inhibitor- to a non-nucleoside reverse transcriptase inhibitor-containing regimen significantly reduced the risk of HF. Multiple switches of HAART did not affect the recovery of CD4 T lymphocytes. CONCLUSION: Multiple sequential HAART regimens do not per se reduce the likelihood of long-term virological suppression and immunological recovery. However, early virological failure increases significantly the risk of subsequent unfavourable virological responses. The choice of a potent initial antiretroviral drug regimen is therefore critical. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/15134189/Long_term_virological_response_to_multiple_sequential_regimens_of_highly_active_antiretroviral_therapy_for_HIV_infection_ L2 - https://ClinicalTrials.gov/search/term=15134189 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -