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Contribution of nitric oxide to adaptation of tibetan sheep to high altitude.
Respir Physiol Neurobiol. 2004 May 20; 140(2):189-96.RP

Abstract

We examined the effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary hemodynamics in awake sheep living at low and high altitudes to evaluate the role of NO in adaptation to an hypoxic environment. Unanaesthetized male sheep in three places--Matsumoto, Japan (680 m above sea level), Xing, China (2300 m) and Maxin, China (3750 m)--were prepared for measurements of pulmonary artery (Ppa) and pulmonary vascular resistance (PVR) before and after the NOS inhibition. The non-selective NOS inhibitor, Nw-nitro-l-argine (NLA, 20 mg/kg) was used. Baseline Ppa became elevated with an increase in altitude. After NLA administration, PVR significantly increased in animals of all groups. However, the increase in PVR after NLA in tibetan sheep at 3750 m was significantly higher than those in other groups. We conclude that augmented endogenous NO production may contribute to regulating the pulmonary vascular tone in tibetan sheep (3750 m) adapted to high altitude.

Authors+Show Affiliations

First Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. tomonobu@hsp.md.shinshu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15134666

Citation

Koizumi, Tomonobu, et al. "Contribution of Nitric Oxide to Adaptation of Tibetan Sheep to High Altitude." Respiratory Physiology & Neurobiology, vol. 140, no. 2, 2004, pp. 189-96.
Koizumi T, Ruan Z, Sakai A, et al. Contribution of nitric oxide to adaptation of tibetan sheep to high altitude. Respir Physiol Neurobiol. 2004;140(2):189-96.
Koizumi, T., Ruan, Z., Sakai, A., Ishizaki, T., Matsumoto, T., Saitou, M., Matsuzaki, T., Kubo, K., Wang, Z., Chen, Q., & Wang, X. (2004). Contribution of nitric oxide to adaptation of tibetan sheep to high altitude. Respiratory Physiology & Neurobiology, 140(2), 189-96.
Koizumi T, et al. Contribution of Nitric Oxide to Adaptation of Tibetan Sheep to High Altitude. Respir Physiol Neurobiol. 2004 May 20;140(2):189-96. PubMed PMID: 15134666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of nitric oxide to adaptation of tibetan sheep to high altitude. AU - Koizumi,Tomonobu, AU - Ruan,Zonghai, AU - Sakai,Akio, AU - Ishizaki,Takeshi, AU - Matsumoto,Takaaki, AU - Saitou,Muneo, AU - Matsuzaki,Tetsuya, AU - Kubo,Keishi, AU - Wang,Zhangang, AU - Chen,Qiuhong, AU - Wang,Xiaoqin, PY - 2003/11/21/accepted PY - 2004/5/12/pubmed PY - 2004/7/20/medline PY - 2004/5/12/entrez SP - 189 EP - 96 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 140 IS - 2 N2 - We examined the effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary hemodynamics in awake sheep living at low and high altitudes to evaluate the role of NO in adaptation to an hypoxic environment. Unanaesthetized male sheep in three places--Matsumoto, Japan (680 m above sea level), Xing, China (2300 m) and Maxin, China (3750 m)--were prepared for measurements of pulmonary artery (Ppa) and pulmonary vascular resistance (PVR) before and after the NOS inhibition. The non-selective NOS inhibitor, Nw-nitro-l-argine (NLA, 20 mg/kg) was used. Baseline Ppa became elevated with an increase in altitude. After NLA administration, PVR significantly increased in animals of all groups. However, the increase in PVR after NLA in tibetan sheep at 3750 m was significantly higher than those in other groups. We conclude that augmented endogenous NO production may contribute to regulating the pulmonary vascular tone in tibetan sheep (3750 m) adapted to high altitude. SN - 1569-9048 UR - https://www.unboundmedicine.com/medline/citation/15134666/Contribution_of_nitric_oxide_to_adaptation_of_tibetan_sheep_to_high_altitude_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569904803002799 DB - PRIME DP - Unbound Medicine ER -