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PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro.
Int Immunopharmacol. 2004 Jun; 4(6):833-9.II

Abstract

Tibetan herbal remedy PADMA 28 revealed promising results to support treatment of intermittent claudication, atherosclerosis and chronic hepatitis. The remedy was confirmed to be closely linked with anti- and pro-oxidative properties in vitro. In this study, effect of PADMA 28 was investigated in stimulated and unstimulated human peripheral blood mononuclear cells (PBMC) in vitro. Neopterin production and tryptophan degradation were measured in supernatants of PBMC in the presence or absence of mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A). Stimulation of PBMC induced neopterin formation and tryptophan degradation (p<0.001 compared to unstimulated PBMC), and PADMA 28 inhibited both immunobiochemical effects (p<0.001) in a concentration-dependent manner. Higher concentrations of PADMA 28 were more effective and were able to completely block the pathways induced upon mitogenic stimulation. Data allow to conclude that PADMA 28 is able to inhibit immunobiological effects in stimulated PBMC in vitro. The suppression of neopterin production and tryptophan degradation suggests a specific influence on biochemical pathways induced by Th1-type cytokine interferon-gamma.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, Leopold Franzens University, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15135323

Citation

Neurauter, G, et al. "PADMA 28 Modulates Interferon-gamma-induced Tryptophan Degradation and Neopterin Production in Human PBMC in Vitro." International Immunopharmacology, vol. 4, no. 6, 2004, pp. 833-9.
Neurauter G, Wirleitner B, Schroecksnadel K, et al. PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. Int Immunopharmacol. 2004;4(6):833-9.
Neurauter, G., Wirleitner, B., Schroecksnadel, K., Schennach, H., Ueberall, F., & Fuchs, D. (2004). PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. International Immunopharmacology, 4(6), 833-9.
Neurauter G, et al. PADMA 28 Modulates Interferon-gamma-induced Tryptophan Degradation and Neopterin Production in Human PBMC in Vitro. Int Immunopharmacol. 2004;4(6):833-9. PubMed PMID: 15135323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. AU - Neurauter,G, AU - Wirleitner,B, AU - Schroecksnadel,K, AU - Schennach,H, AU - Ueberall,F, AU - Fuchs,D, PY - 2004/01/05/received PY - 2004/02/17/revised PY - 2004/03/24/accepted PY - 2004/5/12/pubmed PY - 2004/12/16/medline PY - 2004/5/12/entrez SP - 833 EP - 9 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 4 IS - 6 N2 - Tibetan herbal remedy PADMA 28 revealed promising results to support treatment of intermittent claudication, atherosclerosis and chronic hepatitis. The remedy was confirmed to be closely linked with anti- and pro-oxidative properties in vitro. In this study, effect of PADMA 28 was investigated in stimulated and unstimulated human peripheral blood mononuclear cells (PBMC) in vitro. Neopterin production and tryptophan degradation were measured in supernatants of PBMC in the presence or absence of mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A). Stimulation of PBMC induced neopterin formation and tryptophan degradation (p<0.001 compared to unstimulated PBMC), and PADMA 28 inhibited both immunobiochemical effects (p<0.001) in a concentration-dependent manner. Higher concentrations of PADMA 28 were more effective and were able to completely block the pathways induced upon mitogenic stimulation. Data allow to conclude that PADMA 28 is able to inhibit immunobiological effects in stimulated PBMC in vitro. The suppression of neopterin production and tryptophan degradation suggests a specific influence on biochemical pathways induced by Th1-type cytokine interferon-gamma. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/15135323/PADMA_28_modulates_interferon_gamma_induced_tryptophan_degradation_and_neopterin_production_in_human_PBMC_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(04)00114-6 DB - PRIME DP - Unbound Medicine ER -