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Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation.
Neurosci Lett. 2004 May 06; 361(1-3):229-31.NL

Abstract

A descending facilitatory drive originating from superficial dorsal horn NK1-expressing neurones and relaying through parabrachial and rostroventral medial medulla to act on deep dorsal horn neurones, mediated through spinal 5HT3 receptors, was recently documented. To determine if this pathway plays a role in the pathophysiology of inflammation, we investigated the effects of spinally administered ondansetron (a selective 5HT3 receptor antagonist) on deep dorsal horn neuronal responses in carrageenan inflamed and naïve animals using in vivo electrophysiology. The mechanical and thermal evoked responses of spinal neurones were dose dependently attenuated by ondansetron to a similar degree in both groups. In contrast, the electrically evoked responses (Abeta-, Adelta-, C-fibre evoked response and post-discharge) remained unaltered in both groups. Thus 5HT3 receptor mediated descending facilitation remains unaltered at this stage after tissue injury.

Authors+Show Affiliations

Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. w.rahman@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15135935

Citation

Rahman, Wahida, et al. "Descending Serotonergic Facilitation Mediated Through Rat Spinal 5HT3 Receptors Is Unaltered Following Carrageenan Inflammation." Neuroscience Letters, vol. 361, no. 1-3, 2004, pp. 229-31.
Rahman W, Suzuki R, Rygh LJ, et al. Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. Neurosci Lett. 2004;361(1-3):229-31.
Rahman, W., Suzuki, R., Rygh, L. J., & Dickenson, A. H. (2004). Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. Neuroscience Letters, 361(1-3), 229-31.
Rahman W, et al. Descending Serotonergic Facilitation Mediated Through Rat Spinal 5HT3 Receptors Is Unaltered Following Carrageenan Inflammation. Neurosci Lett. 2004 May 6;361(1-3):229-31. PubMed PMID: 15135935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. AU - Rahman,Wahida, AU - Suzuki,Rie, AU - Rygh,Lars J, AU - Dickenson,Anthony H, PY - 2004/5/12/pubmed PY - 2004/8/31/medline PY - 2004/5/12/entrez SP - 229 EP - 31 JF - Neuroscience letters JO - Neurosci. Lett. VL - 361 IS - 1-3 N2 - A descending facilitatory drive originating from superficial dorsal horn NK1-expressing neurones and relaying through parabrachial and rostroventral medial medulla to act on deep dorsal horn neurones, mediated through spinal 5HT3 receptors, was recently documented. To determine if this pathway plays a role in the pathophysiology of inflammation, we investigated the effects of spinally administered ondansetron (a selective 5HT3 receptor antagonist) on deep dorsal horn neuronal responses in carrageenan inflamed and naïve animals using in vivo electrophysiology. The mechanical and thermal evoked responses of spinal neurones were dose dependently attenuated by ondansetron to a similar degree in both groups. In contrast, the electrically evoked responses (Abeta-, Adelta-, C-fibre evoked response and post-discharge) remained unaltered in both groups. Thus 5HT3 receptor mediated descending facilitation remains unaltered at this stage after tissue injury. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15135935/Descending_serotonergic_facilitation_mediated_through_rat_spinal_5HT3_receptors_is_unaltered_following_carrageenan_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394003015404 DB - PRIME DP - Unbound Medicine ER -