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The effect of reversible inactivation of the supramammillary nucleus on passive avoidance learning in rats.
Behav Brain Res. 2004 Jun 04; 152(1):81-7.BB

Abstract

Previous studies have shown that the presence of hippocampal theta activity is important for learning and memory, and that the medial supramammillary nucleus (mSuM) is involved in the control of the frequency of theta rhythm. It has also been shown that the depression of mSuM activity by chlordiazepoxide causes modest impairment of spatial learning. On the other hand, the lateral supramammillary nucleus (lSum) increases long-term potentiation (LTP) of hippocampal population spikes. However, to our knowledge, no reports exist concerning the role of the supramammillary area (SuM) in passive avoidance (PA) learning. In the present study, rats were chronically implanted with a cannula aimed at SuM and were trained on a step-through PA task. They received intra-SuM injection of lidocaine or saline at the following intervals: 5 min before training, 5, 90, and 360 min after the acquisition trial, or 5 min before the retrieval test. When lidocaine was injected 5 min before training there was no effect on acquisition of PA but retrieval was significantly poorer than the control group injected with saline. Lidocaine injection 5 min after the acquisition trial impaired PA retention, but reversible inactivation of SuM at 90 and 360 min after training and 5 min before the retrieval test showed no significant effect on PA retention. It can be concluded that SuM contributes to PA consolidation at least 5 min after the acquisition trial and that this effect may be accomplished through SuM projections to the septal and/or hippocampal areas participating in the PA memorization processes.

Authors+Show Affiliations

Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, P.O. Box 19835-181, Tehran, Iran. siamakshahidi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15135971

Citation

Shahidi, Siamak, et al. "The Effect of Reversible Inactivation of the Supramammillary Nucleus On Passive Avoidance Learning in Rats." Behavioural Brain Research, vol. 152, no. 1, 2004, pp. 81-7.
Shahidi S, Motamedi F, Bakeshloo SA, et al. The effect of reversible inactivation of the supramammillary nucleus on passive avoidance learning in rats. Behav Brain Res. 2004;152(1):81-7.
Shahidi, S., Motamedi, F., Bakeshloo, S. A., & Taleghani, B. K. (2004). The effect of reversible inactivation of the supramammillary nucleus on passive avoidance learning in rats. Behavioural Brain Research, 152(1), 81-7.
Shahidi S, et al. The Effect of Reversible Inactivation of the Supramammillary Nucleus On Passive Avoidance Learning in Rats. Behav Brain Res. 2004 Jun 4;152(1):81-7. PubMed PMID: 15135971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of reversible inactivation of the supramammillary nucleus on passive avoidance learning in rats. AU - Shahidi,Siamak, AU - Motamedi,Fereshteh, AU - Bakeshloo,Shahrzad Afshar, AU - Taleghani,Behrooz Khakpoor, PY - 2003/01/27/received PY - 2003/09/17/revised PY - 2003/09/22/accepted PY - 2004/5/12/pubmed PY - 2004/7/20/medline PY - 2004/5/12/entrez SP - 81 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 152 IS - 1 N2 - Previous studies have shown that the presence of hippocampal theta activity is important for learning and memory, and that the medial supramammillary nucleus (mSuM) is involved in the control of the frequency of theta rhythm. It has also been shown that the depression of mSuM activity by chlordiazepoxide causes modest impairment of spatial learning. On the other hand, the lateral supramammillary nucleus (lSum) increases long-term potentiation (LTP) of hippocampal population spikes. However, to our knowledge, no reports exist concerning the role of the supramammillary area (SuM) in passive avoidance (PA) learning. In the present study, rats were chronically implanted with a cannula aimed at SuM and were trained on a step-through PA task. They received intra-SuM injection of lidocaine or saline at the following intervals: 5 min before training, 5, 90, and 360 min after the acquisition trial, or 5 min before the retrieval test. When lidocaine was injected 5 min before training there was no effect on acquisition of PA but retrieval was significantly poorer than the control group injected with saline. Lidocaine injection 5 min after the acquisition trial impaired PA retention, but reversible inactivation of SuM at 90 and 360 min after training and 5 min before the retrieval test showed no significant effect on PA retention. It can be concluded that SuM contributes to PA consolidation at least 5 min after the acquisition trial and that this effect may be accomplished through SuM projections to the septal and/or hippocampal areas participating in the PA memorization processes. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15135971/The_effect_of_reversible_inactivation_of_the_supramammillary_nucleus_on_passive_avoidance_learning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166432803003620 DB - PRIME DP - Unbound Medicine ER -