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Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey.
Arch Intern Med. 2004 May 10; 164(9):1010-4.AI

Abstract

BACKGROUND

The biological mechanisms by which depression might increase risk of cardiovascular disease are not clear. Inflammation may be a key element in the development of atherosclerotic cardiovascular disease. Our objective was to determine the association between major depression and elevated C-reactive protein (CRP) level in a nationally representative cohort.

METHODS

We estimated the odds of elevated CRP level (>0.21 mg/mL) associated with depression in 6914 noninstitutionalized men and women (age, 18-39 years) from the Third National Health and Nutrition Examination Survey (NHANES III).

RESULTS

The prevalence of lifetime major depression was 5.7% for men and 11.7% for women. The prevalence of elevated CRP level was 13.7% for men and 27.3% for women. A history of major depression was associated with elevated CRP level (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.20-2.24). The association between depression and CRP was much stronger among men than among women. Results were adjusted for age, African American race, body mass index, total cholesterol, log triglycerides, diabetes, systolic blood pressure, smoking status, alcohol use, estrogen use in women, aspirin use, ibuprofen use, and self-reported health status. Compared with men without a history of depression, CRP levels were higher among men who had a more recent (within 1 year) episode of depression (adjusted OR, 3.00; 95% CI, 1.39-6.48) and who had recurrent (>or=2 episodes) depression (adjusted OR, 3.55; 95% CI, 1.55-8.14).

CONCLUSION

Major depression is strongly associated with increased levels of CRP among men and could help explain the increased risk of cardiovascular disease associated with depression in men.

Authors+Show Affiliations

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. dford@jhmi.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15136311

Citation

Ford, Daniel E., and Thomas P. Erlinger. "Depression and C-reactive Protein in US Adults: Data From the Third National Health and Nutrition Examination Survey." Archives of Internal Medicine, vol. 164, no. 9, 2004, pp. 1010-4.
Ford DE, Erlinger TP. Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2004;164(9):1010-4.
Ford, D. E., & Erlinger, T. P. (2004). Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. Archives of Internal Medicine, 164(9), 1010-4.
Ford DE, Erlinger TP. Depression and C-reactive Protein in US Adults: Data From the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2004 May 10;164(9):1010-4. PubMed PMID: 15136311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey. AU - Ford,Daniel E, AU - Erlinger,Thomas P, PY - 2004/5/12/pubmed PY - 2004/6/21/medline PY - 2004/5/12/entrez SP - 1010 EP - 4 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 164 IS - 9 N2 - BACKGROUND: The biological mechanisms by which depression might increase risk of cardiovascular disease are not clear. Inflammation may be a key element in the development of atherosclerotic cardiovascular disease. Our objective was to determine the association between major depression and elevated C-reactive protein (CRP) level in a nationally representative cohort. METHODS: We estimated the odds of elevated CRP level (>0.21 mg/mL) associated with depression in 6914 noninstitutionalized men and women (age, 18-39 years) from the Third National Health and Nutrition Examination Survey (NHANES III). RESULTS: The prevalence of lifetime major depression was 5.7% for men and 11.7% for women. The prevalence of elevated CRP level was 13.7% for men and 27.3% for women. A history of major depression was associated with elevated CRP level (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.20-2.24). The association between depression and CRP was much stronger among men than among women. Results were adjusted for age, African American race, body mass index, total cholesterol, log triglycerides, diabetes, systolic blood pressure, smoking status, alcohol use, estrogen use in women, aspirin use, ibuprofen use, and self-reported health status. Compared with men without a history of depression, CRP levels were higher among men who had a more recent (within 1 year) episode of depression (adjusted OR, 3.00; 95% CI, 1.39-6.48) and who had recurrent (>or=2 episodes) depression (adjusted OR, 3.55; 95% CI, 1.55-8.14). CONCLUSION: Major depression is strongly associated with increased levels of CRP among men and could help explain the increased risk of cardiovascular disease associated with depression in men. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15136311/Depression_and_C_reactive_protein_in_US_adults:_data_from_the_Third_National_Health_and_Nutrition_Examination_Survey_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.9.1010 DB - PRIME DP - Unbound Medicine ER -