Tags

Type your tag names separated by a space and hit enter

Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
Arch Ophthalmol 2004; 122(5):716-26AO

Abstract

OBJECTIVE

To assess the association of ocular disorders and high doses of antioxidants or zinc with mortality in the Age-Related Eye Disease Study (AREDS).

METHODS

Baseline fundus and lens photographs were used to grade the macular and lens status of AREDS participants. Participants were randomly assigned to receive oral supplements of high-dose antioxidants, zinc, antioxidants plus zinc, or placebo. Risk of all-cause and cause-specific mortality was assessed using adjusted Cox proportional hazards models.

RESULTS

During median follow-up of 6.5 years, 534 (11%) of 4753 AREDS participants died. In fully adjusted models, participants with advanced age-related macular degeneration (AMD) compared with participants with few, if any, drusen had increased mortality (relative risk [RR], 1.41; 95% confidence interval [CI], 1.08-1.86). Advanced AMD was associated with cardiovascular deaths. Compared with participants having good acuity in both eyes, those with visual acuity worse than 20/40 in 1 eye had increased mortality (RR, 1.36; 95% CI, 1.12-1.65). Nuclear opacity (RR, 1.40; 95% CI, 1.12-1.75) and cataract surgery (RR, 1.55; 95% CI, 1.18-2.05) were associated with increased all-cause mortality and with cancer deaths. Participants randomly assigned to receive zinc had lower mortality than those not taking zinc (RR, 0.73; 95% CI, 0.61-0.89).

CONCLUSIONS

The decreased survival of AREDS participants with AMD and cataract suggests that these conditions may reflect systemic rather than only local processes. The improved survival in individuals randomly assigned to receive zinc requires further study.

Authors+Show Affiliations

AREDS Coordinating Center, The EMMES Corp., 401 N. Washington Street, Suite 700, Rockville, MD 20850-1707, USA. aredspub@emmes.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15136320

Citation

Clemons, Traci E., et al. "Associations of Mortality With Ocular Disorders and an Intervention of High-dose Antioxidants and Zinc in the Age-Related Eye Disease Study: AREDS Report No. 13." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 122, no. 5, 2004, pp. 716-26.
Clemons TE, Kurinij N, Sperduto RD, et al. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Arch Ophthalmol. 2004;122(5):716-26.
Clemons, T. E., Kurinij, N., & Sperduto, R. D. (2004). Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Archives of Ophthalmology (Chicago, Ill. : 1960), 122(5), pp. 716-26.
Clemons TE, et al. Associations of Mortality With Ocular Disorders and an Intervention of High-dose Antioxidants and Zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Arch Ophthalmol. 2004;122(5):716-26. PubMed PMID: 15136320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. AU - Clemons,Traci E, AU - Kurinij,Natalie, AU - Sperduto,Robert D, AU - ,, PY - 2004/5/12/pubmed PY - 2004/5/27/medline PY - 2004/5/12/entrez SP - 716 EP - 26 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 122 IS - 5 N2 - OBJECTIVE: To assess the association of ocular disorders and high doses of antioxidants or zinc with mortality in the Age-Related Eye Disease Study (AREDS). METHODS: Baseline fundus and lens photographs were used to grade the macular and lens status of AREDS participants. Participants were randomly assigned to receive oral supplements of high-dose antioxidants, zinc, antioxidants plus zinc, or placebo. Risk of all-cause and cause-specific mortality was assessed using adjusted Cox proportional hazards models. RESULTS: During median follow-up of 6.5 years, 534 (11%) of 4753 AREDS participants died. In fully adjusted models, participants with advanced age-related macular degeneration (AMD) compared with participants with few, if any, drusen had increased mortality (relative risk [RR], 1.41; 95% confidence interval [CI], 1.08-1.86). Advanced AMD was associated with cardiovascular deaths. Compared with participants having good acuity in both eyes, those with visual acuity worse than 20/40 in 1 eye had increased mortality (RR, 1.36; 95% CI, 1.12-1.65). Nuclear opacity (RR, 1.40; 95% CI, 1.12-1.75) and cataract surgery (RR, 1.55; 95% CI, 1.18-2.05) were associated with increased all-cause mortality and with cancer deaths. Participants randomly assigned to receive zinc had lower mortality than those not taking zinc (RR, 0.73; 95% CI, 0.61-0.89). CONCLUSIONS: The decreased survival of AREDS participants with AMD and cataract suggests that these conditions may reflect systemic rather than only local processes. The improved survival in individuals randomly assigned to receive zinc requires further study. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/15136320/Associations_of_mortality_with_ocular_disorders_and_an_intervention_of_high_dose_antioxidants_and_zinc_in_the_Age_Related_Eye_Disease_Study:_AREDS_Report_No__13_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.122.5.716 DB - PRIME DP - Unbound Medicine ER -