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Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study.
BMJ 2004; 328(7451):1285BMJ

Abstract

OBJECTIVE

To evaluate the association of intake of soya food, a rich source of phytoestrogens, with the risk of endometrial cancer.

DESIGN

Population based case-control study, with detailed information on usual soya food intake over the past five years collected by face to face interview using a food frequency questionnaire.

SETTING

Urban Shanghai, China.

PARTICIPANTS

832 incident cases of endometrial cancer in women aged of 30 to 69 years diagnosed during 1997-2001 and identified from the Shanghai Cancer Registry; 846 control women frequency matched to cases on age and randomly selected from the Shanghai Residential Registry.

MAIN OUTCOME MEASURES

Odds ratios for risk of endometrial cancer in women with different intakes of soya foods.

RESULTS

Regular consumption of soya foods, measured as amount of either soya protein or soya isoflavones, was inversely associated with the risk of endometrial cancer. Compared with women with the lowest quarter of intake, the adjusted odds ratio of endometrial cancer was reduced from 0.93 to 0.85 and 0.67 with increasing quarter of soya protein intake (P for trend 0.01). A similar inverse association was observed for soya isoflavones and soya fibre intake. The inverse association seemed to be more pronounced among women with high body mass index and waist:hip ratio.

CONCLUSION

Regular intake of soya foods is associated with a reduced risk of endometrial cancer.

Authors+Show Affiliations

Department of Epidemiology, Shanghai Cancer Institute, 2200 Xie Tu Road #25, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15136343

Citation

Xu, Wang Hong, et al. "Soya Food Intake and Risk of Endometrial Cancer Among Chinese Women in Shanghai: Population Based Case-control Study." BMJ (Clinical Research Ed.), vol. 328, no. 7451, 2004, p. 1285.
Xu WH, Zheng W, Xiang YB, et al. Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. BMJ. 2004;328(7451):1285.
Xu, W. H., Zheng, W., Xiang, Y. B., Ruan, Z. X., Cheng, J. R., Dai, Q., ... Shu, X. O. (2004). Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. BMJ (Clinical Research Ed.), 328(7451), p. 1285.
Xu WH, et al. Soya Food Intake and Risk of Endometrial Cancer Among Chinese Women in Shanghai: Population Based Case-control Study. BMJ. 2004 May 29;328(7451):1285. PubMed PMID: 15136343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. AU - Xu,Wang Hong, AU - Zheng,Wei, AU - Xiang,Yong Bing, AU - Ruan,Zhi Xian, AU - Cheng,Jia Rong, AU - Dai,Qi, AU - Gao,Yu Tang, AU - Shu,Xiao Ou, Y1 - 2004/05/10/ PY - 2004/5/12/pubmed PY - 2004/6/21/medline PY - 2004/5/12/entrez SP - 1285 EP - 1285 JF - BMJ (Clinical research ed.) JO - BMJ VL - 328 IS - 7451 N2 - OBJECTIVE: To evaluate the association of intake of soya food, a rich source of phytoestrogens, with the risk of endometrial cancer. DESIGN: Population based case-control study, with detailed information on usual soya food intake over the past five years collected by face to face interview using a food frequency questionnaire. SETTING: Urban Shanghai, China. PARTICIPANTS: 832 incident cases of endometrial cancer in women aged of 30 to 69 years diagnosed during 1997-2001 and identified from the Shanghai Cancer Registry; 846 control women frequency matched to cases on age and randomly selected from the Shanghai Residential Registry. MAIN OUTCOME MEASURES: Odds ratios for risk of endometrial cancer in women with different intakes of soya foods. RESULTS: Regular consumption of soya foods, measured as amount of either soya protein or soya isoflavones, was inversely associated with the risk of endometrial cancer. Compared with women with the lowest quarter of intake, the adjusted odds ratio of endometrial cancer was reduced from 0.93 to 0.85 and 0.67 with increasing quarter of soya protein intake (P for trend 0.01). A similar inverse association was observed for soya isoflavones and soya fibre intake. The inverse association seemed to be more pronounced among women with high body mass index and waist:hip ratio. CONCLUSION: Regular intake of soya foods is associated with a reduced risk of endometrial cancer. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/15136343/Soya_food_intake_and_risk_of_endometrial_cancer_among_Chinese_women_in_Shanghai:_population_based_case_control_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=15136343 DB - PRIME DP - Unbound Medicine ER -