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Analgesic overuse among subjects with headache, neck, and low-back pain.
Neurology. 2004 May 11; 62(9):1540-4.Neur

Abstract

OBJECTIVES

To examine the prevalence of chronic headache (> or =15 days/month) associated with analgesic overuse in relation to age and gender and the association between analgesic overuse and chronic pain (i.e., migraine, nonmigrainous headache, neck and low-back pain).

METHODS

In the Nord-Trøndelag Health Study 1995 to 1997 (HUNT-2), a total of 51,383 subjects responded to headache questions (Head-HUNT), of which 51,050 completed questions related to musculoskeletal symptoms and 49,064 questions regarding the use of analgesics.

RESULTS

The prevalence of chronic headache associated with analgesic use daily or almost daily for > or =1 month was 1% (1.3% for women and 0.7% for men) and for analgesic overuse duration of > or =3 months 0.9% (1.2% for women and 0.6% for men). Chronic headache was more than seven times more likely among those with analgesic overuse (> or =1 month) than those without (odds ratio [OR] = 7.5, 95% CI: 6.6 to 8.5). Upon analysis of the different chronic pain subgroups separately, the association with analgesic overuse was strongest for chronic migraine (OR = 10.3, 95% CI: 8.1 to 13.0), intermediate for chronic nonmigrainous headache (OR = 6.2, 95% CI: 5.3 to 7.2), and weakest for chronic neck (OR = 2.6, 95% CI: 2.3 to 2.9) and chronic low-back (OR = 3.0, 95% CI: 2.7 to 3.3) pain. The association became stronger with increasing duration of analgesic use for all groups and was most evident among those with headache, especially those with migraine.

CONCLUSIONS

Chronic headache associated with analgesic overuse is prevalent and especially chronic migraine is more strongly associated with frequent intake of analgesics than other common pain conditions like chronic neck and chronic low-back pain.

Authors+Show Affiliations

Zwart JA
Department of Clinical Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. john-anker.zwart@medisin.ntnu.no
Dyb G
No affiliation info available
Hagen K
No affiliation info available
Svebak S
No affiliation info available
Stovner LJ
No affiliation info available
Holmen J
No affiliation info available

MeSH

AdultAge DistributionAnalgesicsChronic DiseaseCross-Sectional StudiesFemaleHeadacheHeadache DisordersHealth StatusHealth SurveysHumansLow Back PainMaleMiddle AgedMigraine DisordersNeck PainNorwayPrevalenceSex DistributionSubstance-Related DisordersSurveys and Questionnaires

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15136678

Citation

Zwart, J-A, et al. "Analgesic Overuse Among Subjects With Headache, Neck, and Low-back Pain." Neurology, vol. 62, no. 9, 2004, pp. 1540-4.
Zwart JA, Dyb G, Hagen K, et al. Analgesic overuse among subjects with headache, neck, and low-back pain. Neurology. 2004;62(9):1540-4.
Zwart, J. A., Dyb, G., Hagen, K., Svebak, S., Stovner, L. J., & Holmen, J. (2004). Analgesic overuse among subjects with headache, neck, and low-back pain. Neurology, 62(9), 1540-4.
Zwart JA, et al. Analgesic Overuse Among Subjects With Headache, Neck, and Low-back Pain. Neurology. 2004 May 11;62(9):1540-4. PubMed PMID: 15136678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic overuse among subjects with headache, neck, and low-back pain. AU - Zwart,J-A, AU - Dyb,G, AU - Hagen,K, AU - Svebak,S, AU - Stovner,L J, AU - Holmen,J, PY - 2004/5/12/pubmed PY - 2004/9/4/medline PY - 2004/5/12/entrez SP - 1540 EP - 4 JF - Neurology JO - Neurology VL - 62 IS - 9 N2 - OBJECTIVES: To examine the prevalence of chronic headache (> or =15 days/month) associated with analgesic overuse in relation to age and gender and the association between analgesic overuse and chronic pain (i.e., migraine, nonmigrainous headache, neck and low-back pain). METHODS: In the Nord-Trøndelag Health Study 1995 to 1997 (HUNT-2), a total of 51,383 subjects responded to headache questions (Head-HUNT), of which 51,050 completed questions related to musculoskeletal symptoms and 49,064 questions regarding the use of analgesics. RESULTS: The prevalence of chronic headache associated with analgesic use daily or almost daily for > or =1 month was 1% (1.3% for women and 0.7% for men) and for analgesic overuse duration of > or =3 months 0.9% (1.2% for women and 0.6% for men). Chronic headache was more than seven times more likely among those with analgesic overuse (> or =1 month) than those without (odds ratio [OR] = 7.5, 95% CI: 6.6 to 8.5). Upon analysis of the different chronic pain subgroups separately, the association with analgesic overuse was strongest for chronic migraine (OR = 10.3, 95% CI: 8.1 to 13.0), intermediate for chronic nonmigrainous headache (OR = 6.2, 95% CI: 5.3 to 7.2), and weakest for chronic neck (OR = 2.6, 95% CI: 2.3 to 2.9) and chronic low-back (OR = 3.0, 95% CI: 2.7 to 3.3) pain. The association became stronger with increasing duration of analgesic use for all groups and was most evident among those with headache, especially those with migraine. CONCLUSIONS: Chronic headache associated with analgesic overuse is prevalent and especially chronic migraine is more strongly associated with frequent intake of analgesics than other common pain conditions like chronic neck and chronic low-back pain. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15136678/Analgesic_overuse_among_subjects_with_headache_neck_and_low_back_pain_ DB - PRIME DP - Unbound Medicine ER -