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Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients.
Eur J Clin Nutr 2004; 58(11):1505-8EJ

Abstract

OBJECTIVE

Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients using an arginine-enhanced formula could improve nutritional variables as well as clinical outcomes.

DESIGN

Randomized clinical trial.

SETTING

Tertiary care.

SUBJECTS

A population of 90 patients with oral and laryngeal cancer was enrolled.

INTERVENTIONS

At surgery, patients were randomly allocated to two groups: (a) patients receiving an arginine-enhanced formula with arginine and fiber (group I) and (b) patients receiving an isocaloric, isonitrogenous formula with fiber enteral formula (group II).

RESULTS

No significant intergroup differences in the trend of the three plasma proteins (albumin, transferrin, prealbumin) and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) was better in group II than I (40% group I and 13% group II: P<0.05). The postoperative complications due to infections were similar in both groups (4% group I and 9% group II: ns). Fistula (wound complication) was less frequent in the enriched nutrition group (5% group I and 11% group II: P<0.05); wound infection was similar in both groups. The length of postoperative stay was better in group I than II (25.8+/-15 days vs 35+/-24.6 days; P<0.05).

CONCLUSIONS

In conclusion, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients and decreases length of stay.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15138461

Citation

de Luis, D A., et al. "Randomized Clinical Trial With an Enteral Arginine-enhanced Formula in Early Postsurgical Head and Neck Cancer Patients." European Journal of Clinical Nutrition, vol. 58, no. 11, 2004, pp. 1505-8.
de Luis DA, Izaola O, Cuellar L, et al. Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. Eur J Clin Nutr. 2004;58(11):1505-8.
de Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., & Aller, R. (2004). Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. European Journal of Clinical Nutrition, 58(11), pp. 1505-8.
de Luis DA, et al. Randomized Clinical Trial With an Enteral Arginine-enhanced Formula in Early Postsurgical Head and Neck Cancer Patients. Eur J Clin Nutr. 2004;58(11):1505-8. PubMed PMID: 15138461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. AU - de Luis,D A, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, AU - Aller,R, PY - 2004/5/13/pubmed PY - 2005/2/11/medline PY - 2004/5/13/entrez SP - 1505 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 11 N2 - OBJECTIVE: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients using an arginine-enhanced formula could improve nutritional variables as well as clinical outcomes. DESIGN: Randomized clinical trial. SETTING: Tertiary care. SUBJECTS: A population of 90 patients with oral and laryngeal cancer was enrolled. INTERVENTIONS: At surgery, patients were randomly allocated to two groups: (a) patients receiving an arginine-enhanced formula with arginine and fiber (group I) and (b) patients receiving an isocaloric, isonitrogenous formula with fiber enteral formula (group II). RESULTS: No significant intergroup differences in the trend of the three plasma proteins (albumin, transferrin, prealbumin) and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) was better in group II than I (40% group I and 13% group II: P<0.05). The postoperative complications due to infections were similar in both groups (4% group I and 9% group II: ns). Fistula (wound complication) was less frequent in the enriched nutrition group (5% group I and 11% group II: P<0.05); wound infection was similar in both groups. The length of postoperative stay was better in group I than II (25.8+/-15 days vs 35+/-24.6 days; P<0.05). CONCLUSIONS: In conclusion, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients and decreases length of stay. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15138461/Randomized_clinical_trial_with_an_enteral_arginine_enhanced_formula_in_early_postsurgical_head_and_neck_cancer_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601999 DB - PRIME DP - Unbound Medicine ER -