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Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis.
J Neurol Sci. 2004 May 15; 220(1-2):73-8.JN

Abstract

Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis.

Authors+Show Affiliations

Department of Neurology, Yongdong Severance Hospital, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15140609

Citation

Lee, Kyung Yul, et al. "Persistent Increase of Matrix Metalloproteinases in Cerebrospinal Fluid of Tuberculous Meningitis." Journal of the Neurological Sciences, vol. 220, no. 1-2, 2004, pp. 73-8.
Lee KY, Kim EH, Yang WS, et al. Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis. J Neurol Sci. 2004;220(1-2):73-8.
Lee, K. Y., Kim, E. H., Yang, W. S., Ryu, H., Cho, S. N., Lee, B. I., & Heo, J. H. (2004). Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis. Journal of the Neurological Sciences, 220(1-2), 73-8.
Lee KY, et al. Persistent Increase of Matrix Metalloproteinases in Cerebrospinal Fluid of Tuberculous Meningitis. J Neurol Sci. 2004 May 15;220(1-2):73-8. PubMed PMID: 15140609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis. AU - Lee,Kyung Yul, AU - Kim,Eun Hee, AU - Yang,Won Seok, AU - Ryu,Hyunjeong, AU - Cho,Sang-Nae, AU - Lee,Byung In, AU - Heo,Ji Hoe, PY - 2003/11/24/received PY - 2004/02/06/revised PY - 2004/02/06/accepted PY - 2004/5/14/pubmed PY - 2004/7/23/medline PY - 2004/5/14/entrez SP - 73 EP - 8 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 220 IS - 1-2 N2 - Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15140609/Persistent_increase_of_matrix_metalloproteinases_in_cerebrospinal_fluid_of_tuberculous_meningitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X04000371 DB - PRIME DP - Unbound Medicine ER -