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Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD.
J Neurol Sci. 2004 May 15; 220(1-2):105-11.JN

Abstract

OBJECTIVE

Cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy studies of patients with idiopathic Parkinson's disease (PD) found decreased uptake. Whether this decrease is associated with clinical severity as assessed by the Unified Parkinson's Disease Rating Scale (UPDRS) and the phenotypes of PD has not been determined.

METHODS

Cardiac MIBG scintigraphy was performed on 34 patients with PD, 7 with multiple system atrophy (MSA), 4 with dementia with Lewy bodies (DLB), and 11 normal controls (NCs). Early and delayed MIBG heart/mediastinum (H/M) ratios were evaluated. PD severity was assessed by the Hoehn and Yahr (H-Y) stage and UPDRS. Patients were grouped in two phenotypes, tremor and postural instability gait difficulty (PIGD)-dominant groups based on UPDRS components. Associations between MIBG uptake and age at onset, UPDRS, and disease phenotype were analyzed in each group.

RESULTS

The early H/M ratio was significantly lower in patients with PD (1.45+/-0.207) than in the NCs (2.08+/-0.231), and in those with MSA (1.99+/-0.284), but not in those with DLB (1.29+/-0.0435). The delayed H/M ratio for PD (1.33+/-0.276) also was significantly decreased as compared to the ratios for NCs (2.17+/-0.286) and MSA (2.16+/-0.414) but not DLB (1.16+/-0.0949). The early H/M ratio was significantly correlated with both UPDRS score and age at onset, whereas the delayed H/M ratio only was significantly correlated with age at onset. The PIGD-dominant group had significantly higher UPDRS scores and lower H/M ratios than the tremor-dominant group.

CONCLUSION

Cardiac MIBG scintigraphy can be used to differentiate PD from MSA and NC, and to determine the disease severity and phenotypes of PD.

Authors+Show Affiliations

Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0923, Japan. saibon@kanazawa-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15140615

Citation

Saiki, Shinji, et al. "Cardiac 123I-MIBG Scintigraphy Can Assess the Disease Severity and Phenotype of PD." Journal of the Neurological Sciences, vol. 220, no. 1-2, 2004, pp. 105-11.
Saiki S, Hirose G, Sakai K, et al. Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD. J Neurol Sci. 2004;220(1-2):105-11.
Saiki, S., Hirose, G., Sakai, K., Kataoka, S., Hori, A., Saiki, M., Kaito, M., Higashi, K., Taki, S., Kakeshita, K., Fujino, S., & Miaki, M. (2004). Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD. Journal of the Neurological Sciences, 220(1-2), 105-11.
Saiki S, et al. Cardiac 123I-MIBG Scintigraphy Can Assess the Disease Severity and Phenotype of PD. J Neurol Sci. 2004 May 15;220(1-2):105-11. PubMed PMID: 15140615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD. AU - Saiki,Shinji, AU - Hirose,Genjiro, AU - Sakai,Koichiro, AU - Kataoka,Satoshi, AU - Hori,Ariyuki, AU - Saiki,Misuzu, AU - Kaito,Muichi, AU - Higashi,Kotaro, AU - Taki,Suzuka, AU - Kakeshita,Kazuo, AU - Fujino,Susumu, AU - Miaki,Miho, PY - 2003/07/02/received PY - 2003/11/25/revised PY - 2004/02/25/accepted PY - 2004/5/14/pubmed PY - 2004/7/23/medline PY - 2004/5/14/entrez SP - 105 EP - 11 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 220 IS - 1-2 N2 - OBJECTIVE: Cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy studies of patients with idiopathic Parkinson's disease (PD) found decreased uptake. Whether this decrease is associated with clinical severity as assessed by the Unified Parkinson's Disease Rating Scale (UPDRS) and the phenotypes of PD has not been determined. METHODS: Cardiac MIBG scintigraphy was performed on 34 patients with PD, 7 with multiple system atrophy (MSA), 4 with dementia with Lewy bodies (DLB), and 11 normal controls (NCs). Early and delayed MIBG heart/mediastinum (H/M) ratios were evaluated. PD severity was assessed by the Hoehn and Yahr (H-Y) stage and UPDRS. Patients were grouped in two phenotypes, tremor and postural instability gait difficulty (PIGD)-dominant groups based on UPDRS components. Associations between MIBG uptake and age at onset, UPDRS, and disease phenotype were analyzed in each group. RESULTS: The early H/M ratio was significantly lower in patients with PD (1.45+/-0.207) than in the NCs (2.08+/-0.231), and in those with MSA (1.99+/-0.284), but not in those with DLB (1.29+/-0.0435). The delayed H/M ratio for PD (1.33+/-0.276) also was significantly decreased as compared to the ratios for NCs (2.17+/-0.286) and MSA (2.16+/-0.414) but not DLB (1.16+/-0.0949). The early H/M ratio was significantly correlated with both UPDRS score and age at onset, whereas the delayed H/M ratio only was significantly correlated with age at onset. The PIGD-dominant group had significantly higher UPDRS scores and lower H/M ratios than the tremor-dominant group. CONCLUSION: Cardiac MIBG scintigraphy can be used to differentiate PD from MSA and NC, and to determine the disease severity and phenotypes of PD. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15140615/Cardiac_123I_MIBG_scintigraphy_can_assess_the_disease_severity_and_phenotype_of_PD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X04000619 DB - PRIME DP - Unbound Medicine ER -