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Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials.
Clin Otolaryngol Allied Sci. 2004 Jun; 29(3):226-31.CO

Abstract

The objective was to ascertain if Ginkgo biloba benefits patients with tinnitus. The study design was: 1. Randomized double blind trial of Ginkgo biloba versus placebo; 2. A meta-analysis of randomized placebo controlled double blind trials. Participants included 66 adult patients with tinnitus and six (including our study) randomized placebo controlled double blind trials were meta-analysed. The main outcome measures were the Tinnitus Handicap Inventory (THI), Glasgow Health Status Inventory (GHSI) and average of hearing threshold at 0.5, 1, 2, 4 kHz. In the meta-analysis the proportion of patients gaining benefit and an overall odds ratio were determined. The results showed the mean difference in change of the THI, GHSI and hearing between Ginkgo biloba (n = 31) and placebo group (n = 29) was 2.51 (CI -10.1, 5.1, P = 0.51), 0.58 (CI-4.8, 3.6, P = 0.38) and 0.68 db (CI -4.13, 2.8, P = 0.69). Meta-analysis revealed 21.6% of Ginkgo biloba treated patients (n = 107/552) gained benefit versus 18.4% (n = 87/504) of placebo treated patients with an odds ratio of 1.24 (CI 0.89, 1.71). In conclusion, Ginkgo biloba does not benefit patients with tinnitus.

Authors+Show Affiliations

Department of Otolaryngology, Monklands Hospital, Airdrie, UK. dariusrejali@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Meta-Analysis
Randomized Controlled Trial

Language

eng

PubMed ID

15142066

Citation

Rejali, D, et al. "Ginkgo Biloba Does Not Benefit Patients With Tinnitus: a Randomized Placebo-controlled Double-blind Trial and Meta-analysis of Randomized Trials." Clinical Otolaryngology and Allied Sciences, vol. 29, no. 3, 2004, pp. 226-31.
Rejali D, Sivakumar A, Balaji N. Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. Clin Otolaryngol Allied Sci. 2004;29(3):226-31.
Rejali, D., Sivakumar, A., & Balaji, N. (2004). Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. Clinical Otolaryngology and Allied Sciences, 29(3), 226-31.
Rejali D, Sivakumar A, Balaji N. Ginkgo Biloba Does Not Benefit Patients With Tinnitus: a Randomized Placebo-controlled Double-blind Trial and Meta-analysis of Randomized Trials. Clin Otolaryngol Allied Sci. 2004;29(3):226-31. PubMed PMID: 15142066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. AU - Rejali,D, AU - Sivakumar,A, AU - Balaji,N, PY - 2004/5/15/pubmed PY - 2004/9/24/medline PY - 2004/5/15/entrez SP - 226 EP - 31 JF - Clinical otolaryngology and allied sciences JO - Clin Otolaryngol Allied Sci VL - 29 IS - 3 N2 - The objective was to ascertain if Ginkgo biloba benefits patients with tinnitus. The study design was: 1. Randomized double blind trial of Ginkgo biloba versus placebo; 2. A meta-analysis of randomized placebo controlled double blind trials. Participants included 66 adult patients with tinnitus and six (including our study) randomized placebo controlled double blind trials were meta-analysed. The main outcome measures were the Tinnitus Handicap Inventory (THI), Glasgow Health Status Inventory (GHSI) and average of hearing threshold at 0.5, 1, 2, 4 kHz. In the meta-analysis the proportion of patients gaining benefit and an overall odds ratio were determined. The results showed the mean difference in change of the THI, GHSI and hearing between Ginkgo biloba (n = 31) and placebo group (n = 29) was 2.51 (CI -10.1, 5.1, P = 0.51), 0.58 (CI-4.8, 3.6, P = 0.38) and 0.68 db (CI -4.13, 2.8, P = 0.69). Meta-analysis revealed 21.6% of Ginkgo biloba treated patients (n = 107/552) gained benefit versus 18.4% (n = 87/504) of placebo treated patients with an odds ratio of 1.24 (CI 0.89, 1.71). In conclusion, Ginkgo biloba does not benefit patients with tinnitus. SN - 0307-7772 UR - https://www.unboundmedicine.com/medline/citation/15142066/Ginkgo_biloba_does_not_benefit_patients_with_tinnitus:_a_randomized_placebo_controlled_double_blind_trial_and_meta_analysis_of_randomized_trials_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0307-7772&date=2004&volume=29&issue=3&spage=226 DB - PRIME DP - Unbound Medicine ER -