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Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.
Science. 2004 May 14; 304(5673):1021-4.Sci

Abstract

Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP. In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production. These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity.

Authors+Show Affiliations

Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15143284

Citation

Liu, Lidong, et al. "Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity." Science (New York, N.Y.), vol. 304, no. 5673, 2004, pp. 1021-4.
Liu L, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004;304(5673):1021-4.
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004). Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science (New York, N.Y.), 304(5673), 1021-4.
Liu L, et al. Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity. Science. 2004 May 14;304(5673):1021-4. PubMed PMID: 15143284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. AU - Liu,Lidong, AU - Wong,Tak Pan, AU - Pozza,Mario F, AU - Lingenhoehl,Kurt, AU - Wang,Yushan, AU - Sheng,Morgan, AU - Auberson,Yves P, AU - Wang,Yu Tian, PY - 2004/5/15/pubmed PY - 2004/5/22/medline PY - 2004/5/15/entrez SP - 1021 EP - 4 JF - Science (New York, N.Y.) JO - Science VL - 304 IS - 5673 N2 - Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP. In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production. These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/15143284/Role_of_NMDA_receptor_subtypes_in_governing_the_direction_of_hippocampal_synaptic_plasticity_ DB - PRIME DP - Unbound Medicine ER -