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[Effects of glutamine granules on protein metabolism in trauma patients].
Zhonghua Wai Ke Za Zhi. 2004 Apr 07; 42(7):406-9.ZW

Abstract

OBJECTIVE

To evaluate the effect of glutamine granules on protein metabolism in severe burns and trauma patients.

METHODS

120 patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients). There was isonitrogenous and isocaloric intake in both groups, GLN and P group patents had been given glutamine granules or placebo (glycine) at 0.5 g.kg(-1).d(-1) for 7 days, respectively. The level of plasma glutamine, protein and urine nitrogen exclude were determined, wound healing rate of burn area and hospital stay were recorded, and then observed the complication and side effect.

RESULTS

After 7 days of taking glutamine granules orally, plasma GLN concentration was significant higher than that in P group (592.50 +/- 185.23 micro mol/L vs. 407.41 +/- 190.22 micro mol/L) (P < 0.01). Plasma prealbumin and transferrin in GLN group were significant higher than those in P group (P < 0.01), but the concentration of total protein and albumin were no marked changes compare with P group (P > 0.05). The capacity of urine nitrogen exclude in GLN group were significant lower than that in P group. Additional, the wound healing rate was faster and hospital stay days was shorter than P group (P < 0.05), and the occurrence of glutamine granules side effect was seldom.

CONCLUSION

Taking glutamine could promote protein synthesis, abate protein decompose, ameliorate wound healing rate and reduce hospital stay obviously.

Authors+Show Affiliations

Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

chi

PubMed ID

15144667

Citation

Peng, Xi, et al. "[Effects of Glutamine Granules On Protein Metabolism in Trauma Patients]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 42, no. 7, 2004, pp. 406-9.
Peng X, You ZY, Huang XK, et al. [Effects of glutamine granules on protein metabolism in trauma patients]. Zhonghua Wai Ke Za Zhi. 2004;42(7):406-9.
Peng, X., You, Z. Y., Huang, X. K., Zhang, S. Q., He, G. Z., Xie, W. G., & Quan, Z. F. (2004). [Effects of glutamine granules on protein metabolism in trauma patients]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 42(7), 406-9.
Peng X, et al. [Effects of Glutamine Granules On Protein Metabolism in Trauma Patients]. Zhonghua Wai Ke Za Zhi. 2004 Apr 7;42(7):406-9. PubMed PMID: 15144667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of glutamine granules on protein metabolism in trauma patients]. AU - Peng,Xi, AU - You,Zhong-yi, AU - Huang,Xian-kai, AU - Zhang,Shao-quan, AU - He,Guang-zhao, AU - Xie,Wei-guang, AU - Quan,Zhu-fu, PY - 2004/5/18/pubmed PY - 2004/10/8/medline PY - 2004/5/18/entrez SP - 406 EP - 9 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 42 IS - 7 N2 - OBJECTIVE: To evaluate the effect of glutamine granules on protein metabolism in severe burns and trauma patients. METHODS: 120 patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients). There was isonitrogenous and isocaloric intake in both groups, GLN and P group patents had been given glutamine granules or placebo (glycine) at 0.5 g.kg(-1).d(-1) for 7 days, respectively. The level of plasma glutamine, protein and urine nitrogen exclude were determined, wound healing rate of burn area and hospital stay were recorded, and then observed the complication and side effect. RESULTS: After 7 days of taking glutamine granules orally, plasma GLN concentration was significant higher than that in P group (592.50 +/- 185.23 micro mol/L vs. 407.41 +/- 190.22 micro mol/L) (P < 0.01). Plasma prealbumin and transferrin in GLN group were significant higher than those in P group (P < 0.01), but the concentration of total protein and albumin were no marked changes compare with P group (P > 0.05). The capacity of urine nitrogen exclude in GLN group were significant lower than that in P group. Additional, the wound healing rate was faster and hospital stay days was shorter than P group (P < 0.05), and the occurrence of glutamine granules side effect was seldom. CONCLUSION: Taking glutamine could promote protein synthesis, abate protein decompose, ameliorate wound healing rate and reduce hospital stay obviously. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/15144667/[Effects_of_glutamine_granules_on_protein_metabolism_in_trauma_patients]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-5815&amp;year=2004&amp;vol=42&amp;issue=7&amp;fpage=406 DB - PRIME DP - Unbound Medicine ER -