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Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm.
Eur J Cardiothorac Surg. 2004 Jun; 25(6):1006-10.EJ

Abstract

OBJECTIVES

Brief episodes of myocardial ischemia-reperfusion employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of postconditioning on persistent reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart model.

METHODS

Isolated Langendorff-perfused rat hearts (n = 46) were subjected to 30 min of regional ischemia and reperfusion. The hearts with persistent VF (n = 11) present after 15 min of reperfusion were then randomly assigned into one of the two groups: (1) control hearts (n = 6) in which perfusion was continued without intervention; (2) postconditioned hearts (n = 5) subjected to 2 min of global ischemia followed by reperfusion. Left ventricular pressures, heart rate, coronary flow, and electrogram were monitored throughout the experiment.

RESULTS

Conversion of VF into regular rhythm was observed in all hearts subjected to postconditioning. Regular beating was maintained by all postconditioned hearts during the subsequent reperfusion. None of the hearts in the control group had normal rhythm at the end of the experiment. At the end of reperfusion, the left ventricular developed pressure was lower in beating postconditioned hearts compared to the hearts that did not develop persistent VF.

CONCLUSIONS

Ischemic postconditioning possesses strong antiarrhythmic effect against persistent reperfusion-induced tachyarrhythmias. Postconditioning may be an interesting, novel adjunct strategy to protect the heart.

Authors+Show Affiliations

Galagudza M
Department of Pathophysiology and Laboratory of Circulation, St. Petersburg I.P. Pavlov Federal Medical University, Russian Federation.
Kurapeev D
No affiliation info available
Minasian S
No affiliation info available
Valen G
No affiliation info available
Vaage J
No affiliation info available

MeSH

AnimalsConstrictionCoronary CirculationHeart RateHemodynamicsMaleMyocardial ReperfusionMyocardial Reperfusion InjuryRatsRats, WistarVentricular Fibrillation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15145002

Citation

Galagudza, Michael, et al. "Ischemic Postconditioning: Brief Ischemia During Reperfusion Converts Persistent Ventricular Fibrillation Into Regular Rhythm." European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery, vol. 25, no. 6, 2004, pp. 1006-10.
Galagudza M, Kurapeev D, Minasian S, et al. Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm. Eur J Cardiothorac Surg. 2004;25(6):1006-10.
Galagudza, M., Kurapeev, D., Minasian, S., Valen, G., & Vaage, J. (2004). Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm. European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery, 25(6), 1006-10.
Galagudza M, et al. Ischemic Postconditioning: Brief Ischemia During Reperfusion Converts Persistent Ventricular Fibrillation Into Regular Rhythm. Eur J Cardiothorac Surg. 2004;25(6):1006-10. PubMed PMID: 15145002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm. AU - Galagudza,Michael, AU - Kurapeev,Dmitry, AU - Minasian,Sarkis, AU - Valen,Guro, AU - Vaage,Jarle, PY - 2003/12/13/received PY - 2004/02/03/revised PY - 2004/02/04/accepted PY - 2004/5/18/pubmed PY - 2004/10/13/medline PY - 2004/5/18/entrez SP - 1006 EP - 10 JF - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery JO - Eur J Cardiothorac Surg VL - 25 IS - 6 N2 - OBJECTIVES: Brief episodes of myocardial ischemia-reperfusion employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of postconditioning on persistent reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart model. METHODS: Isolated Langendorff-perfused rat hearts (n = 46) were subjected to 30 min of regional ischemia and reperfusion. The hearts with persistent VF (n = 11) present after 15 min of reperfusion were then randomly assigned into one of the two groups: (1) control hearts (n = 6) in which perfusion was continued without intervention; (2) postconditioned hearts (n = 5) subjected to 2 min of global ischemia followed by reperfusion. Left ventricular pressures, heart rate, coronary flow, and electrogram were monitored throughout the experiment. RESULTS: Conversion of VF into regular rhythm was observed in all hearts subjected to postconditioning. Regular beating was maintained by all postconditioned hearts during the subsequent reperfusion. None of the hearts in the control group had normal rhythm at the end of the experiment. At the end of reperfusion, the left ventricular developed pressure was lower in beating postconditioned hearts compared to the hearts that did not develop persistent VF. CONCLUSIONS: Ischemic postconditioning possesses strong antiarrhythmic effect against persistent reperfusion-induced tachyarrhythmias. Postconditioning may be an interesting, novel adjunct strategy to protect the heart. SN - 1010-7940 UR - https://www.unboundmedicine.com/medline/citation/15145002/Ischemic_postconditioning:_brief_ischemia_during_reperfusion_converts_persistent_ventricular_fibrillation_into_regular_rhythm_ DB - PRIME DP - Unbound Medicine ER -