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A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan.
Int J Radiat Oncol Biol Phys. 2004 Jun 01; 59(2):495-500.IJ

Abstract

PURPOSE

A multi-institutional retrospective study was performed in northern Japan to analyze the outcome of external radiotherapy as the definitive treatment modality for localized mucosal melanoma of the head and neck.

PATIENTS AND METHODS

Thirty-one patients with localized mucosal melanoma of the head and neck treated by external radiotherapy at nine institutions of the Northern Japan Radiation Therapy Oncology Group between 1980 and 1999 were enrolled in this study. Radiotherapy alone was performed in 21 patients, and the remaining 10 patients received postoperative radiotherapy for gross residual tumors. The fraction size of radiotherapy varied from 1.5-13.8 Gy, with the total dose ranging from 32-64 Gy (median, 50 Gy). The follow-up periods ranged from 1-214 months (median, 16 months).

RESULTS

Complete or partial responses were observed in 9 patients (29%) and 18 patients (58%), respectively. Local recurrence occurred in 13 patients (41.9%) and distant metastasis occurred in 11 patients (35.5%). Most incidences of local recurrence and distant metastasis developed within 2 years after the initial treatment. Overall cause-specific survival rates of patients at 1 and 3 years were 73% and 33%, respectively. Univariate analysis showed that high dose per fractionated radiotherapy doses (>or=3 Gy) was associated with better prognosis for both local control (p = 0.048) and survival (p = 0.045). Multivariate analysis indicated that age (better prognosis in younger patients, p = 0.046) was the only significant factor. Radiotherapy for gross residual lesions after surgery did not seem to impact the significant gain of local control and survival. We observed two fatal late complications of mucosal ulcer and bleeding in the high dose per fractionated radiotherapy group.

CONCLUSION

Radiotherapy at a dose of 3 Gy or more per fraction was effective in gaining local control in patients with localized mucosal melanoma of the head and neck, and subsequently better survival was possible, especially in younger patients.

Authors+Show Affiliations

Northern Japanese Radiation Therapy Oncology Group, Department of Radiology, Yamagata City Hospital, Yamagata, Japan. wadajin@rad.med.tohoku.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

15145168

Citation

Wada, Hitoshi, et al. "A Multi-institutional Retrospective Analysis of External Radiotherapy for Mucosal Melanoma of the Head and Neck in Northern Japan." International Journal of Radiation Oncology, Biology, Physics, vol. 59, no. 2, 2004, pp. 495-500.
Wada H, Nemoto K, Ogawa Y, et al. A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan. Int J Radiat Oncol Biol Phys. 2004;59(2):495-500.
Wada, H., Nemoto, K., Ogawa, Y., Hareyama, M., Yoshida, H., Takamura, A., Ohmori, K., Hamamoto, Y., Sugita, T., Saitoh, M., & Yamada, S. (2004). A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan. International Journal of Radiation Oncology, Biology, Physics, 59(2), 495-500.
Wada H, et al. A Multi-institutional Retrospective Analysis of External Radiotherapy for Mucosal Melanoma of the Head and Neck in Northern Japan. Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):495-500. PubMed PMID: 15145168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan. AU - Wada,Hitoshi, AU - Nemoto,Kenji, AU - Ogawa,Yoshihiro, AU - Hareyama,Masato, AU - Yoshida,Hiroshi, AU - Takamura,Akio, AU - Ohmori,Keiichi, AU - Hamamoto,Yasushi, AU - Sugita,Tadashi, AU - Saitoh,Mari, AU - Yamada,Shogo, PY - 2003/07/14/received PY - 2003/10/27/revised PY - 2003/11/04/accepted PY - 2004/5/18/pubmed PY - 2004/6/29/medline PY - 2004/5/18/entrez SP - 495 EP - 500 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 59 IS - 2 N2 - PURPOSE: A multi-institutional retrospective study was performed in northern Japan to analyze the outcome of external radiotherapy as the definitive treatment modality for localized mucosal melanoma of the head and neck. PATIENTS AND METHODS: Thirty-one patients with localized mucosal melanoma of the head and neck treated by external radiotherapy at nine institutions of the Northern Japan Radiation Therapy Oncology Group between 1980 and 1999 were enrolled in this study. Radiotherapy alone was performed in 21 patients, and the remaining 10 patients received postoperative radiotherapy for gross residual tumors. The fraction size of radiotherapy varied from 1.5-13.8 Gy, with the total dose ranging from 32-64 Gy (median, 50 Gy). The follow-up periods ranged from 1-214 months (median, 16 months). RESULTS: Complete or partial responses were observed in 9 patients (29%) and 18 patients (58%), respectively. Local recurrence occurred in 13 patients (41.9%) and distant metastasis occurred in 11 patients (35.5%). Most incidences of local recurrence and distant metastasis developed within 2 years after the initial treatment. Overall cause-specific survival rates of patients at 1 and 3 years were 73% and 33%, respectively. Univariate analysis showed that high dose per fractionated radiotherapy doses (>or=3 Gy) was associated with better prognosis for both local control (p = 0.048) and survival (p = 0.045). Multivariate analysis indicated that age (better prognosis in younger patients, p = 0.046) was the only significant factor. Radiotherapy for gross residual lesions after surgery did not seem to impact the significant gain of local control and survival. We observed two fatal late complications of mucosal ulcer and bleeding in the high dose per fractionated radiotherapy group. CONCLUSION: Radiotherapy at a dose of 3 Gy or more per fraction was effective in gaining local control in patients with localized mucosal melanoma of the head and neck, and subsequently better survival was possible, especially in younger patients. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/15145168/A_multi_institutional_retrospective_analysis_of_external_radiotherapy_for_mucosal_melanoma_of_the_head_and_neck_in_Northern_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360301603023071 DB - PRIME DP - Unbound Medicine ER -