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mRNA export: an assembly line from genes to nuclear pores.
Curr Opin Cell Biol. 2004 Jun; 16(3):285-92.CO

Abstract

mRNAs are transported from the nucleus to the cytoplasm by a machinery conserved from yeast to humans. Previous studies showed that mRNA export factors are loaded on nascent mRNAs during elongation, coupling transcription to export. More recently identified mRNA export factors connect transcription initiation to the export machinery associated with nuclear pores, and potentially tether active genes to the nuclear periphery. Furthermore, a newly identified link between the nuclear exosome and the transcription, 3'-end formation and export machineries suggests that early messenger ribonucleoprotein complex (mRNP) assembly is co-transcriptionally monitored. Moreover, inefficient mRNP assembly impairs transcription elongation, indicating tight interdependence of these processes. Finally, nuclear retention of unspliced mRNAs by the perinuclear Mlp proteins reveals a novel mechanism of mRNP surveillance prior to export.

Authors+Show Affiliations

Department of Cell Biology, University of Geneva, Sciences III, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15145353

Citation

Vinciguerra, Patrizia, and Françoise Stutz. "MRNA Export: an Assembly Line From Genes to Nuclear Pores." Current Opinion in Cell Biology, vol. 16, no. 3, 2004, pp. 285-92.
Vinciguerra P, Stutz F. MRNA export: an assembly line from genes to nuclear pores. Curr Opin Cell Biol. 2004;16(3):285-92.
Vinciguerra, P., & Stutz, F. (2004). MRNA export: an assembly line from genes to nuclear pores. Current Opinion in Cell Biology, 16(3), 285-92.
Vinciguerra P, Stutz F. MRNA Export: an Assembly Line From Genes to Nuclear Pores. Curr Opin Cell Biol. 2004;16(3):285-92. PubMed PMID: 15145353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - mRNA export: an assembly line from genes to nuclear pores. AU - Vinciguerra,Patrizia, AU - Stutz,Françoise, PY - 2004/5/18/pubmed PY - 2005/10/29/medline PY - 2004/5/18/entrez SP - 285 EP - 92 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 16 IS - 3 N2 - mRNAs are transported from the nucleus to the cytoplasm by a machinery conserved from yeast to humans. Previous studies showed that mRNA export factors are loaded on nascent mRNAs during elongation, coupling transcription to export. More recently identified mRNA export factors connect transcription initiation to the export machinery associated with nuclear pores, and potentially tether active genes to the nuclear periphery. Furthermore, a newly identified link between the nuclear exosome and the transcription, 3'-end formation and export machineries suggests that early messenger ribonucleoprotein complex (mRNP) assembly is co-transcriptionally monitored. Moreover, inefficient mRNP assembly impairs transcription elongation, indicating tight interdependence of these processes. Finally, nuclear retention of unspliced mRNAs by the perinuclear Mlp proteins reveals a novel mechanism of mRNP surveillance prior to export. SN - 0955-0674 UR - https://www.unboundmedicine.com/medline/citation/15145353/mRNA_export:_an_assembly_line_from_genes_to_nuclear_pores_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955067404000511 DB - PRIME DP - Unbound Medicine ER -