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Oral simvastatin treatment in relapsing-remitting multiple sclerosis.
Lancet 2004; 363(9421):1607-8Lct

Abstract

Many drugs have been approved for relapsing forms of multiple sclerosis but are only partly effective, are injected, and are expensive. We aimed to investigate use of of oral simvastatin (80 mg) in 30 individuals with relapsing-remitting multiple sclerosis. The mean number of gadolinium-enhancing lesions at months 4, 5, and 6 of treatment was compared with the mean number of lesions noted on pretreatment brain MRI scans. Number and volume of Gd-enhancing lesions declined by 44%, (p<0.0001) and 41% (p=0.0018), respectively. Treatment was well tolerated. Oral simvastatin might inhibit inflammatory components of multiple sclerosis that lead to neurological disability.

Authors+Show Affiliations

Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15145635

Citation

Vollmer, Timothy, et al. "Oral Simvastatin Treatment in Relapsing-remitting Multiple Sclerosis." Lancet (London, England), vol. 363, no. 9421, 2004, pp. 1607-8.
Vollmer T, Key L, Durkalski V, et al. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet. 2004;363(9421):1607-8.
Vollmer, T., Key, L., Durkalski, V., Tyor, W., Corboy, J., Markovic-Plese, S., ... Singh, I. (2004). Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet (London, England), 363(9421), pp. 1607-8.
Vollmer T, et al. Oral Simvastatin Treatment in Relapsing-remitting Multiple Sclerosis. Lancet. 2004 May 15;363(9421):1607-8. PubMed PMID: 15145635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral simvastatin treatment in relapsing-remitting multiple sclerosis. AU - Vollmer,Timothy, AU - Key,Lyndon, AU - Durkalski,Valerie, AU - Tyor,William, AU - Corboy,John, AU - Markovic-Plese,Silva, AU - Preiningerova,Jana, AU - Rizzo,Marco, AU - Singh,Inderjit, PY - 2004/5/18/pubmed PY - 2004/5/28/medline PY - 2004/5/18/entrez SP - 1607 EP - 8 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9421 N2 - Many drugs have been approved for relapsing forms of multiple sclerosis but are only partly effective, are injected, and are expensive. We aimed to investigate use of of oral simvastatin (80 mg) in 30 individuals with relapsing-remitting multiple sclerosis. The mean number of gadolinium-enhancing lesions at months 4, 5, and 6 of treatment was compared with the mean number of lesions noted on pretreatment brain MRI scans. Number and volume of Gd-enhancing lesions declined by 44%, (p<0.0001) and 41% (p=0.0018), respectively. Treatment was well tolerated. Oral simvastatin might inhibit inflammatory components of multiple sclerosis that lead to neurological disability. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/15145635/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(04)16205-3 DB - PRIME DP - Unbound Medicine ER -