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Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test.
Eur J Pharmacol. 2004 May 10; 492(1):61-3.EJ

Abstract

Chronic antidepressant treatments enhance dopaminergic neurotransmission in the mesolimbic dopamine system. We suggested that this potentiation might underlie both the antidepressant therapeutic effect and the antidepressant-induced switch from depression to mania. In a recent study we have shown a reversal of the imipramine-induced dopaminergic supersensitivity after 40 days of chronic imipramine withdrawal. We interpreted this result suggesting that the mood-switches observed in bipolar patients following antidepressant treatment and subsequent withdrawal, i.e. mania followed by rebound depression, might depend upon parallel changes in the mesolimbic dopamine system sensitivity. On this basis, one might predict a depressive-like behaviour after long-term interruption of a chronic treatment with imipramine. To test this hypothesis we examined the behaviour of rats treated with chronic imipramine 40 days after treatment interruption in an animal model of depression, the forced swimming test. The results show that animals treated with chronic imipramine, 40 days after treatment interruption, display a depressive-like behaviour in the forced swimming test, as indicated by their increased immobility with respect to the control group.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, via Muroni 23/a, 07100 Sassari, Italy. dsfpaolo@ssmain.uniss.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15145707

Citation

D'Aquila, Paolo S., et al. "Long-term Imipramine Withdrawal Induces a Depressive-like Behaviour in the Forced Swimming Test." European Journal of Pharmacology, vol. 492, no. 1, 2004, pp. 61-3.
D'Aquila PS, Panin F, Serra G. Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test. Eur J Pharmacol. 2004;492(1):61-3.
D'Aquila, P. S., Panin, F., & Serra, G. (2004). Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test. European Journal of Pharmacology, 492(1), 61-3.
D'Aquila PS, Panin F, Serra G. Long-term Imipramine Withdrawal Induces a Depressive-like Behaviour in the Forced Swimming Test. Eur J Pharmacol. 2004 May 10;492(1):61-3. PubMed PMID: 15145707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test. AU - D'Aquila,Paolo S, AU - Panin,Francesca, AU - Serra,Gino, PY - 2004/03/24/received PY - 2004/04/01/accepted PY - 2004/5/18/pubmed PY - 2005/1/19/medline PY - 2004/5/18/entrez SP - 61 EP - 3 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 492 IS - 1 N2 - Chronic antidepressant treatments enhance dopaminergic neurotransmission in the mesolimbic dopamine system. We suggested that this potentiation might underlie both the antidepressant therapeutic effect and the antidepressant-induced switch from depression to mania. In a recent study we have shown a reversal of the imipramine-induced dopaminergic supersensitivity after 40 days of chronic imipramine withdrawal. We interpreted this result suggesting that the mood-switches observed in bipolar patients following antidepressant treatment and subsequent withdrawal, i.e. mania followed by rebound depression, might depend upon parallel changes in the mesolimbic dopamine system sensitivity. On this basis, one might predict a depressive-like behaviour after long-term interruption of a chronic treatment with imipramine. To test this hypothesis we examined the behaviour of rats treated with chronic imipramine 40 days after treatment interruption in an animal model of depression, the forced swimming test. The results show that animals treated with chronic imipramine, 40 days after treatment interruption, display a depressive-like behaviour in the forced swimming test, as indicated by their increased immobility with respect to the control group. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15145707/Long_term_imipramine_withdrawal_induces_a_depressive_like_behaviour_in_the_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299904003838 DB - PRIME DP - Unbound Medicine ER -