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Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists.
Brain Res. 2004 May 22; 1008(2):155-67.BR

Abstract

Triadimefon (TDF) is a triazole fungicide that blocks the reuptake of dopamine (DA), much like cocaine. A recent study in our laboratory found that intermittent injections of TDF led to robust locomotor sensitization in response to challenge TDF after a 2-week withdrawal period. The current study sought to determine whether the expression of TDF behavioral sensitization could be prevented by the DA D1-like receptor antagonist SCH 23390 (SCH), the DA D2-like receptor antagonist remoxipride (Rem), the competitive NMDA antagonist CPP, or the AMPA antagonist NBQX. Adult male C57/BL6 mice were injected with vehicle or 75 mg/kg TDF twice a week for 7 weeks, with locomotor activity measured periodically across the 14 doses. After a 2-week withdrawal period, mice were pretreated with SCH (0.015 mg/kg), Rem (0.3 mg/kg), CPP (2.5 mg/kg) or NBQX (10.0 mg/kg) followed 30 min later by vehicle or 75 mg/kg TDF and tested for the expression of TDF sensitization. Intermittent administration of TDF led to the development and robust expression of behavioral sensitization in terms of vertical activity. Pretreatment with SCH, NBQX and CPP successfully blocked the expression of vertical sensitization to TDF, while Rem pretreatment did not. All four antagonists, however, attenuated the neurochemical changes normally associated with TDF sensitization as measured 8 h after the 2-week TDF challenge. This paper reveals that NMDA, AMPA and DA D1-like receptors are necessary for the behavioral expression of sensitization to the fungicide triadimefon.

Authors+Show Affiliations

Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15145752

Citation

Reeves, R, et al. "Expression of Behavioral Sensitization to the Cocaine-like Fungicide Triadimefon Is Blocked By Pretreatment With AMPA, NMDA and DA D1 Receptor Antagonists." Brain Research, vol. 1008, no. 2, 2004, pp. 155-67.
Reeves R, Thiruchelvam M, Cory-Slechta DA. Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists. Brain Res. 2004;1008(2):155-67.
Reeves, R., Thiruchelvam, M., & Cory-Slechta, D. A. (2004). Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists. Brain Research, 1008(2), 155-67.
Reeves R, Thiruchelvam M, Cory-Slechta DA. Expression of Behavioral Sensitization to the Cocaine-like Fungicide Triadimefon Is Blocked By Pretreatment With AMPA, NMDA and DA D1 Receptor Antagonists. Brain Res. 2004 May 22;1008(2):155-67. PubMed PMID: 15145752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists. AU - Reeves,R, AU - Thiruchelvam,M, AU - Cory-Slechta,D A, PY - 2004/01/18/accepted PY - 2004/5/18/pubmed PY - 2004/7/22/medline PY - 2004/5/18/entrez SP - 155 EP - 67 JF - Brain research JO - Brain Res VL - 1008 IS - 2 N2 - Triadimefon (TDF) is a triazole fungicide that blocks the reuptake of dopamine (DA), much like cocaine. A recent study in our laboratory found that intermittent injections of TDF led to robust locomotor sensitization in response to challenge TDF after a 2-week withdrawal period. The current study sought to determine whether the expression of TDF behavioral sensitization could be prevented by the DA D1-like receptor antagonist SCH 23390 (SCH), the DA D2-like receptor antagonist remoxipride (Rem), the competitive NMDA antagonist CPP, or the AMPA antagonist NBQX. Adult male C57/BL6 mice were injected with vehicle or 75 mg/kg TDF twice a week for 7 weeks, with locomotor activity measured periodically across the 14 doses. After a 2-week withdrawal period, mice were pretreated with SCH (0.015 mg/kg), Rem (0.3 mg/kg), CPP (2.5 mg/kg) or NBQX (10.0 mg/kg) followed 30 min later by vehicle or 75 mg/kg TDF and tested for the expression of TDF sensitization. Intermittent administration of TDF led to the development and robust expression of behavioral sensitization in terms of vertical activity. Pretreatment with SCH, NBQX and CPP successfully blocked the expression of vertical sensitization to TDF, while Rem pretreatment did not. All four antagonists, however, attenuated the neurochemical changes normally associated with TDF sensitization as measured 8 h after the 2-week TDF challenge. This paper reveals that NMDA, AMPA and DA D1-like receptors are necessary for the behavioral expression of sensitization to the fungicide triadimefon. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15145752/Expression_of_behavioral_sensitization_to_the_cocaine_like_fungicide_triadimefon_is_blocked_by_pretreatment_with_AMPA_NMDA_and_DA_D1_receptor_antagonists_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899304002653 DB - PRIME DP - Unbound Medicine ER -