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[Treatment of insulin-dependent diabetes: new therapy by electromagnetic replacement: towards an artificial pancreas].
Bull Acad Natl Med. 2003; 187(7):1285-94; discussion 1295.BA

Abstract

The goal of treatment of diabetes mellitus is the achievement of sustained normoglycemia to prevent the complications with the lowest incidence of hypoglycemia. In the same time, it attempts to reduce the hourly and daily constraints due to multiple injections and self monitoring of glycemia. Both intermittent injections and subcutaneous route are inappropriated to extreme precision and flexibility of regulation requested to reach optimal glycemic control and the best quality of life in most diabetic people. The progress in biomaterials and micro-electronics, the availability of stable insulin solutions have permitted to implant a pump with an awaited functional autonomy for 10 years and to perfuse insulin by peritoneal way in a continuous and modulable fashion. The intra-vascular implanted enzymatic glucose sensors, using glucose-oxidase, are able to measure with good accuracy real-time blood glucose for the duration from 6 to 12 months. The combination of these two linked devices implanted in type 1 diabetic patients has given the opportunity to perform the first trials for periods of 48 hours delivering automated insulin according to glycemic variability. This most physiological restoration of insulin function is feasible and appears to represent a possibility for long term treatment of diabetics.

Authors+Show Affiliations

CHU Hôpital Lapeyronie, 371 avenue du doyen Gaston Géraud-34295 Montpellier.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

15146604

Citation

Bringer, Jacques, et al. "[Treatment of Insulin-dependent Diabetes: New Therapy By Electromagnetic Replacement: Towards an Artificial Pancreas]." Bulletin De l'Academie Nationale De Medecine, vol. 187, no. 7, 2003, pp. 1285-94; discussion 1295.
Bringer J, Costalat G, Jaffiol C, et al. [Treatment of insulin-dependent diabetes: new therapy by electromagnetic replacement: towards an artificial pancreas]. Bull Acad Natl Med. 2003;187(7):1285-94; discussion 1295.
Bringer, J., Costalat, G., Jaffiol, C., & Renard, E. (2003). [Treatment of insulin-dependent diabetes: new therapy by electromagnetic replacement: towards an artificial pancreas]. Bulletin De l'Academie Nationale De Medecine, 187(7), 1285-94; discussion 1295.
Bringer J, et al. [Treatment of Insulin-dependent Diabetes: New Therapy By Electromagnetic Replacement: Towards an Artificial Pancreas]. Bull Acad Natl Med. 2003;187(7):1285-94; discussion 1295. PubMed PMID: 15146604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of insulin-dependent diabetes: new therapy by electromagnetic replacement: towards an artificial pancreas]. AU - Bringer,Jacques, AU - Costalat,Guy, AU - Jaffiol,Claude, AU - Renard,Eric, PY - 2004/5/19/pubmed PY - 2004/6/2/medline PY - 2004/5/19/entrez SP - 1285-94; discussion 1295 JF - Bulletin de l'Academie nationale de medecine JO - Bull Acad Natl Med VL - 187 IS - 7 N2 - The goal of treatment of diabetes mellitus is the achievement of sustained normoglycemia to prevent the complications with the lowest incidence of hypoglycemia. In the same time, it attempts to reduce the hourly and daily constraints due to multiple injections and self monitoring of glycemia. Both intermittent injections and subcutaneous route are inappropriated to extreme precision and flexibility of regulation requested to reach optimal glycemic control and the best quality of life in most diabetic people. The progress in biomaterials and micro-electronics, the availability of stable insulin solutions have permitted to implant a pump with an awaited functional autonomy for 10 years and to perfuse insulin by peritoneal way in a continuous and modulable fashion. The intra-vascular implanted enzymatic glucose sensors, using glucose-oxidase, are able to measure with good accuracy real-time blood glucose for the duration from 6 to 12 months. The combination of these two linked devices implanted in type 1 diabetic patients has given the opportunity to perform the first trials for periods of 48 hours delivering automated insulin according to glycemic variability. This most physiological restoration of insulin function is feasible and appears to represent a possibility for long term treatment of diabetics. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/15146604/[Treatment_of_insulin_dependent_diabetes:_new_therapy_by_electromagnetic_replacement:_towards_an_artificial_pancreas]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -