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1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action.
Endocr Regul 2004; 38(1):29-38ER

Abstract

Vitamin D is considered multifunctional steroid hormone that modulates calcium homeostasis through actions predominantly in kidney, bone and the intestinal tract. Nuclear vitamin D receptor (VDR) is a specific nuclear protein, a member of steroid hormone receptor superfamily. The amino acid sequence of the VDR shows a significant homology with other members of the nuclear hormone receptor superfamily, including receptors for glucocorticoids (GR), oestrogen (ER), androgen (AR), progesteron (PR), thyroid hormone (T3R), retinoic acid (RAR), retinoid X (RXR) and over 150 orphan receptors. VDR is known to mediate the pleiotropic biological actions of 1a,25-dihydroxyvitamin D3 through its ability to modulate the expression of target genes. VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes. The VDR has been shown to associate with several additional molecules to form the active transcriptional complex required for gene regulation. The regulation of this ligand-activated cellular transcription factor occurs at both transcriptional and posttranslational levels. This article summarizes a variety of effects of 1a,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor, and its use in chemotherapy and chemoprevention of cancer.

Authors+Show Affiliations

Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 833 06 Bratislava, Slovakia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15147236

Citation

Nezbedova, P, and J Brtko. "1alpha,25-dihydroxyvitamin D3 Inducible Transcription Factor and Its Role in the Vitamin D Action." Endocrine Regulations, vol. 38, no. 1, 2004, pp. 29-38.
Nezbedova P, Brtko J. 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action. Endocr Regul. 2004;38(1):29-38.
Nezbedova, P., & Brtko, J. (2004). 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action. Endocrine Regulations, 38(1), pp. 29-38.
Nezbedova P, Brtko J. 1alpha,25-dihydroxyvitamin D3 Inducible Transcription Factor and Its Role in the Vitamin D Action. Endocr Regul. 2004;38(1):29-38. PubMed PMID: 15147236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action. AU - Nezbedova,P, AU - Brtko,J, PY - 2004/5/19/pubmed PY - 2004/12/16/medline PY - 2004/5/19/entrez SP - 29 EP - 38 JF - Endocrine regulations JO - Endocr Regul VL - 38 IS - 1 N2 - Vitamin D is considered multifunctional steroid hormone that modulates calcium homeostasis through actions predominantly in kidney, bone and the intestinal tract. Nuclear vitamin D receptor (VDR) is a specific nuclear protein, a member of steroid hormone receptor superfamily. The amino acid sequence of the VDR shows a significant homology with other members of the nuclear hormone receptor superfamily, including receptors for glucocorticoids (GR), oestrogen (ER), androgen (AR), progesteron (PR), thyroid hormone (T3R), retinoic acid (RAR), retinoid X (RXR) and over 150 orphan receptors. VDR is known to mediate the pleiotropic biological actions of 1a,25-dihydroxyvitamin D3 through its ability to modulate the expression of target genes. VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes. The VDR has been shown to associate with several additional molecules to form the active transcriptional complex required for gene regulation. The regulation of this ligand-activated cellular transcription factor occurs at both transcriptional and posttranslational levels. This article summarizes a variety of effects of 1a,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor, and its use in chemotherapy and chemoprevention of cancer. SN - 1210-0668 UR - https://www.unboundmedicine.com/medline/citation/15147236/1alpha25_dihydroxyvitamin_D3_inducible_transcription_factor_and_its_role_in_the_vitamin_D_action_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=ER&file=2004_01_29.pdf DB - PRIME DP - Unbound Medicine ER -