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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.
Arch Neurol 2004; 61(5):661-6AN

Abstract

BACKGROUND

Few prospective studies have assessed diabetes mellitus as a risk factor for incident Alzheimer disease (AD) and decline in cognitive function.

OBJECTIVE

To evaluate the association of diabetes mellitus with risk of AD and change in different cognitive systems.

DESIGN

Longitudinal cohort study.

PARTICIPANTS

For up to 9 years, 824 older (those >55 years) Catholic nuns, priests, and brothers underwent detailed annual clinical evaluations.

MAIN OUTCOME MEASURES

Clinically diagnosed AD and change in global and specific measures of cognitive function.

RESULTS

Diabetes mellitus was present in 127 (15.4%) of the participants. During a mean of 5.5 years of observation, 151 persons developed AD. In a proportional hazards model adjusted for age, sex, and educational level, those with diabetes mellitus had a 65% increase in the risk of developing AD compared with those without diabetes mellitus (hazard ratio, 1.65; 95% confidence interval, 1.10-2.47). In random effects models, diabetes mellitus was associated with lower levels of global cognition, episodic memory, semantic memory, working memory, and visuospatial ability at baseline. Diabetes mellitus was associated with a 44% greater rate of decline in perceptual speed (P =.02), but not in other cognitive systems.

CONCLUSIONS

Diabetes mellitus may be associated with an increased risk of developing AD and may affect cognitive systems differentially.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, the Department of Neurological Sciences, and the Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15148141

Citation

Arvanitakis, Zoe, et al. "Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function." Archives of Neurology, vol. 61, no. 5, 2004, pp. 661-6.
Arvanitakis Z, Wilson RS, Bienias JL, et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol. 2004;61(5):661-6.
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004). Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of Neurology, 61(5), pp. 661-6.
Arvanitakis Z, et al. Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function. Arch Neurol. 2004;61(5):661-6. PubMed PMID: 15148141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. AU - Arvanitakis,Zoe, AU - Wilson,Robert S, AU - Bienias,Julia L, AU - Evans,Denis A, AU - Bennett,David A, PY - 2004/5/19/pubmed PY - 2004/6/18/medline PY - 2004/5/19/entrez SP - 661 EP - 6 JF - Archives of neurology JO - Arch. Neurol. VL - 61 IS - 5 N2 - BACKGROUND: Few prospective studies have assessed diabetes mellitus as a risk factor for incident Alzheimer disease (AD) and decline in cognitive function. OBJECTIVE: To evaluate the association of diabetes mellitus with risk of AD and change in different cognitive systems. DESIGN: Longitudinal cohort study. PARTICIPANTS: For up to 9 years, 824 older (those >55 years) Catholic nuns, priests, and brothers underwent detailed annual clinical evaluations. MAIN OUTCOME MEASURES: Clinically diagnosed AD and change in global and specific measures of cognitive function. RESULTS: Diabetes mellitus was present in 127 (15.4%) of the participants. During a mean of 5.5 years of observation, 151 persons developed AD. In a proportional hazards model adjusted for age, sex, and educational level, those with diabetes mellitus had a 65% increase in the risk of developing AD compared with those without diabetes mellitus (hazard ratio, 1.65; 95% confidence interval, 1.10-2.47). In random effects models, diabetes mellitus was associated with lower levels of global cognition, episodic memory, semantic memory, working memory, and visuospatial ability at baseline. Diabetes mellitus was associated with a 44% greater rate of decline in perceptual speed (P =.02), but not in other cognitive systems. CONCLUSIONS: Diabetes mellitus may be associated with an increased risk of developing AD and may affect cognitive systems differentially. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15148141/Diabetes_mellitus_and_risk_of_Alzheimer_disease_and_decline_in_cognitive_function_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.61.5.661 DB - PRIME DP - Unbound Medicine ER -