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Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates.
Calcif Tissue Int. 2004 Sep; 75(3):189-96.CT

Abstract

The aim of this study was to evaluate the efficacy and safety of risedronate and pamidronate in 30 patients (mean age = 57.86 +/- 8.90 years) with severe Paget's disease of bone (PDB), showing acquired resistance to intravenous (IV) clodronate treatment. Fifteen patients were treated with oral risedronate (30 mg/day for 8 weeks). Treatment was repeated in patients without evidence of PDB remission [total alkaline phosphatase (tALP) serum levels in the normal range] at day 120. Fifteen patients were treated with IV pamidronate (30 mg/day for 3 days). Pamidronate treatment (60 mg/day for 3 days) was repeated in patients without evidence of PDB remission at day 120. At day 60, a significant decrease in tALP serum levels was obtained in all pagetic patients. At day 360, 13 (86.6%) patients treated with risedronate achieved PDB remission, 9 patients during the initial treatment and 4 after retreatment. Two patients showed a significant decrease in tALP serum levels without clinical remission after two risedronate treatments. At the same time, 12 (80%) patients treated with pamidronate achieved PDB remission, 6 patients during the first treatment and 6 after retreatment. Three patients showed a significant decrease in tALP serum levels but no clinical remission after two pamidronate courses. Two of these patients showed a relapse during the study. The incidence of minor side effects and transient hyperparathyroidism related to bisphosphonate treatment was significantly lower after risedronate therapy. In patients with resistant PDB, oral risedronate therapy has comparable efficacy to IV pamidronate with a lower incidence of treatment-related side effects.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Federico II University Medical School, 80131 Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15148558

Citation

Rendina, D, et al. "Risedronate and Pamidronate Treatment in the Clinical Management of Patients With Severe Paget's Disease of Bone and Acquired Resistance to Bisphosphonates." Calcified Tissue International, vol. 75, no. 3, 2004, pp. 189-96.
Rendina D, Mossetti G, Viceconti R, et al. Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates. Calcif Tissue Int. 2004;75(3):189-96.
Rendina, D., Mossetti, G., Viceconti, R., Sorrentino, M., & Nunziata, V. (2004). Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates. Calcified Tissue International, 75(3), 189-96.
Rendina D, et al. Risedronate and Pamidronate Treatment in the Clinical Management of Patients With Severe Paget's Disease of Bone and Acquired Resistance to Bisphosphonates. Calcif Tissue Int. 2004;75(3):189-96. PubMed PMID: 15148558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates. AU - Rendina,D, AU - Mossetti,G, AU - Viceconti,R, AU - Sorrentino,M, AU - Nunziata,V, PY - 2004/5/19/pubmed PY - 2005/2/23/medline PY - 2004/5/19/entrez SP - 189 EP - 96 JF - Calcified tissue international JO - Calcif Tissue Int VL - 75 IS - 3 N2 - The aim of this study was to evaluate the efficacy and safety of risedronate and pamidronate in 30 patients (mean age = 57.86 +/- 8.90 years) with severe Paget's disease of bone (PDB), showing acquired resistance to intravenous (IV) clodronate treatment. Fifteen patients were treated with oral risedronate (30 mg/day for 8 weeks). Treatment was repeated in patients without evidence of PDB remission [total alkaline phosphatase (tALP) serum levels in the normal range] at day 120. Fifteen patients were treated with IV pamidronate (30 mg/day for 3 days). Pamidronate treatment (60 mg/day for 3 days) was repeated in patients without evidence of PDB remission at day 120. At day 60, a significant decrease in tALP serum levels was obtained in all pagetic patients. At day 360, 13 (86.6%) patients treated with risedronate achieved PDB remission, 9 patients during the initial treatment and 4 after retreatment. Two patients showed a significant decrease in tALP serum levels without clinical remission after two risedronate treatments. At the same time, 12 (80%) patients treated with pamidronate achieved PDB remission, 6 patients during the first treatment and 6 after retreatment. Three patients showed a significant decrease in tALP serum levels but no clinical remission after two pamidronate courses. Two of these patients showed a relapse during the study. The incidence of minor side effects and transient hyperparathyroidism related to bisphosphonate treatment was significantly lower after risedronate therapy. In patients with resistant PDB, oral risedronate therapy has comparable efficacy to IV pamidronate with a lower incidence of treatment-related side effects. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/15148558/Risedronate_and_pamidronate_treatment_in_the_clinical_management_of_patients_with_severe_Paget's_disease_of_bone_and_acquired_resistance_to_bisphosphonates_ L2 - https://dx.doi.org/10.1007/s00223-004-0103-3 DB - PRIME DP - Unbound Medicine ER -