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Carnitines and male infertility.

Abstract

L-Carnitine (LC) and acetyl-L-carnitine (ALC) are highly concentrated in the epididymis and play a crucial role in sperm metabolism and maturation. They are related to sperm motility and have antioxidant properties. The objective of this review is to summarize the multiple roles played by LC and ALC in male reproduction, and to highlight their limitations as well as their benefits in the treatment of male infertility. A variety of studies support the conclusion that LC and/or ALC at total daily amounts of at least 3 g per day can significantly improve both sperm concentration and total sperm counts among men with astheno- or oligoasthenozoospermia. Although many clinical trials have demonstrated the beneficial effects of LC and ALC in selected cases of male infertility, the majority of these studies suffer from a lack of placebo-controlled, double blind design, making it difficult to reach a definite conclusion. Additional, well-designed studies are necessary to further validate the use of carnitines in the treatment of patients with male infertility, specifically in men with poor semen quality.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A19.1, Cleveland, OH 44195, USA. agarwaa@ccf.org

    Source

    Reproductive biomedicine online 8:4 2004 Apr pg 376-84

    MeSH

    Acetylcarnitine
    Antioxidants
    Carnitine
    Humans
    Infertility, Male
    Male
    Oligospermia
    Sperm Count
    Sperm Motility

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15149558

    Citation

    Agarwal, A, and Tamer M. Said. "Carnitines and Male Infertility." Reproductive Biomedicine Online, vol. 8, no. 4, 2004, pp. 376-84.
    Agarwal A, Said TM. Carnitines and male infertility. Reprod Biomed Online. 2004;8(4):376-84.
    Agarwal, A., & Said, T. M. (2004). Carnitines and male infertility. Reproductive Biomedicine Online, 8(4), pp. 376-84.
    Agarwal A, Said TM. Carnitines and Male Infertility. Reprod Biomed Online. 2004;8(4):376-84. PubMed PMID: 15149558.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carnitines and male infertility. AU - Agarwal,A, AU - Said,Tamer M, PY - 2004/5/20/pubmed PY - 2004/10/20/medline PY - 2004/5/20/entrez SP - 376 EP - 84 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 8 IS - 4 N2 - L-Carnitine (LC) and acetyl-L-carnitine (ALC) are highly concentrated in the epididymis and play a crucial role in sperm metabolism and maturation. They are related to sperm motility and have antioxidant properties. The objective of this review is to summarize the multiple roles played by LC and ALC in male reproduction, and to highlight their limitations as well as their benefits in the treatment of male infertility. A variety of studies support the conclusion that LC and/or ALC at total daily amounts of at least 3 g per day can significantly improve both sperm concentration and total sperm counts among men with astheno- or oligoasthenozoospermia. Although many clinical trials have demonstrated the beneficial effects of LC and ALC in selected cases of male infertility, the majority of these studies suffer from a lack of placebo-controlled, double blind design, making it difficult to reach a definite conclusion. Additional, well-designed studies are necessary to further validate the use of carnitines in the treatment of patients with male infertility, specifically in men with poor semen quality. SN - 1472-6483 UR - https://www.unboundmedicine.com/medline/citation/15149558/Carnitines_and_male_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)60920-0 DB - PRIME DP - Unbound Medicine ER -