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Moderate exercise improves antibody response to influenza immunization in older adults.
Vaccine 2004; 22(17-18):2298-306V

Abstract

Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults >or=age 64 were assigned to an exercise group (n= 14) or a control group (n = 13). The subjects exercised at 65-75% heart rate reserve (HRR), 25-30 min, 3 days per week, for 10 months. Controls did not change activity. Subjects were immunized with trivalent influenza vaccine before and after the exercise intervention. After the exercise intervention, exercisers exhibited a greater mean fold increase (MFI) in antibody titer to influenza A/New Caledonia/20/99 (H1N1) and A/Panama/2007/99 (H3N2) than controls, and a greater Granzyme B activity to A/Panama/2007/99 than controls. These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine.

Authors+Show Affiliations

Department of Health and Human Performance/Immunobiology, Iowa State University, 235 Forker Building, Ames, IA 50011, USA. mkohut@iastate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15149789

Citation

Kohut, Marian L., et al. "Moderate Exercise Improves Antibody Response to Influenza Immunization in Older Adults." Vaccine, vol. 22, no. 17-18, 2004, pp. 2298-306.
Kohut ML, Arntson BA, Lee W, et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004;22(17-18):2298-306.
Kohut, M. L., Arntson, B. A., Lee, W., Rozeboom, K., Yoon, K. J., Cunnick, J. E., & McElhaney, J. (2004). Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine, 22(17-18), pp. 2298-306.
Kohut ML, et al. Moderate Exercise Improves Antibody Response to Influenza Immunization in Older Adults. Vaccine. 2004 Jun 2;22(17-18):2298-306. PubMed PMID: 15149789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate exercise improves antibody response to influenza immunization in older adults. AU - Kohut,Marian L, AU - Arntson,Barbara A, AU - Lee,Wanglok, AU - Rozeboom,Kayla, AU - Yoon,Kyoung-Jin, AU - Cunnick,Joan E, AU - McElhaney,Janet, PY - 2003/03/13/received PY - 2003/10/20/revised PY - 2003/11/04/accepted PY - 2004/5/20/pubmed PY - 2005/1/19/medline PY - 2004/5/20/entrez SP - 2298 EP - 306 JF - Vaccine JO - Vaccine VL - 22 IS - 17-18 N2 - Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults >or=age 64 were assigned to an exercise group (n= 14) or a control group (n = 13). The subjects exercised at 65-75% heart rate reserve (HRR), 25-30 min, 3 days per week, for 10 months. Controls did not change activity. Subjects were immunized with trivalent influenza vaccine before and after the exercise intervention. After the exercise intervention, exercisers exhibited a greater mean fold increase (MFI) in antibody titer to influenza A/New Caledonia/20/99 (H1N1) and A/Panama/2007/99 (H3N2) than controls, and a greater Granzyme B activity to A/Panama/2007/99 than controls. These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/15149789/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264410X03008181 DB - PRIME DP - Unbound Medicine ER -