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Moderate exercise improves antibody response to influenza immunization in older adults.

Abstract

Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults >or=age 64 were assigned to an exercise group (n= 14) or a control group (n = 13). The subjects exercised at 65-75% heart rate reserve (HRR), 25-30 min, 3 days per week, for 10 months. Controls did not change activity. Subjects were immunized with trivalent influenza vaccine before and after the exercise intervention. After the exercise intervention, exercisers exhibited a greater mean fold increase (MFI) in antibody titer to influenza A/New Caledonia/20/99 (H1N1) and A/Panama/2007/99 (H3N2) than controls, and a greater Granzyme B activity to A/Panama/2007/99 than controls. These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine.

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  • Publisher Full Text
  • Authors

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    Source

    Vaccine 22:17-18 2004 Jun 2 pg 2298-306

    MeSH

    Adult
    Aged
    Aging
    Antibodies, Viral
    Exercise
    Female
    Granzymes
    Humans
    Influenza A virus
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Serine Endopeptidases
    Vaccination

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15149789

    Citation

    TY - JOUR T1 - Moderate exercise improves antibody response to influenza immunization in older adults. AU - Kohut,Marian L, AU - Arntson,Barbara A, AU - Lee,Wanglok, AU - Rozeboom,Kayla, AU - Yoon,Kyoung-Jin, AU - Cunnick,Joan E, AU - McElhaney,Janet, PY - 2004/5/20/pubmed PY - 2005/1/19/medline PY - 2003/Mar/13/received PY - 2003/Oct/20/revised PY - 2003/Nov/4/accepted PY - 2004/5/20/entrez SP - 2298 EP - 306 JF - Vaccine JO - Vaccine VL - 22 IS - 17-18 N2 - Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults >or=age 64 were assigned to an exercise group (n= 14) or a control group (n = 13). The subjects exercised at 65-75% heart rate reserve (HRR), 25-30 min, 3 days per week, for 10 months. Controls did not change activity. Subjects were immunized with trivalent influenza vaccine before and after the exercise intervention. After the exercise intervention, exercisers exhibited a greater mean fold increase (MFI) in antibody titer to influenza A/New Caledonia/20/99 (H1N1) and A/Panama/2007/99 (H3N2) than controls, and a greater Granzyme B activity to A/Panama/2007/99 than controls. These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/15149789/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S0264410X03008181 ER -